Responses of isolated bronchial muscle to ganglionically active drugs / by D.F. Hawkins and W.D.M. Paton.

  • Hawkins, D. F. (Denis Frank)
Date:
[1958?]
Catalogue details

Licence: In copyright

Credit: Responses of isolated bronchial muscle to ganglionically active drugs / by D.F. Hawkins and W.D.M. Paton. Source: Wellcome Collection.

    4/28 (page 196)
    We therefore proceeded to test further the possibility that there might be situated in the tissue ganglion cells possessing a bronchodilator action. Hexamethonium. The response to nicotine was reduced by hexamethonium when present in a concentration of 0*1 p,g/ml. (Fig. 2 a). Such low concentra- Hexamethonium 10 6 Eig. 2. Guinea-pig tracheal chain, (a) Effect of hexamethonium 10-7 on responses to 2 mg nicotine at 45 min intervals, hexamethonium added to bath 30 min before third dose of nicotine; (b) effect of hexamethonium 10“6 on various doses of nicotine, showing approxi¬ mately 20-fold antagonism. tions of hexamethonium rarely show any action other than that of ganglion paralysis. The antagonism of the nicotine relaxation by these concentrations of hexamethonium therefore increased the likelihood that the nicotine action is