On the pathology of pernicious anaemia / by Walter K. Hunter, M.D., B.Sc.

  • Hunter, Walter King.
Date:
[1897?]
Catalogue details

Licence: Public Domain Mark

Credit: On the pathology of pernicious anaemia / by Walter K. Hunter, M.D., B.Sc. Source: Wellcome Collection.

Provider: This material has been provided by The University of Glasgow Library. The original may be consulted at The University of Glasgow Library.

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    attacks of diarrhoea and bleeding at the nose. A less degree of anaemia had existed for some four or five years, dating from an attack of rheumatism, since which time there had been shortness of breath and other evidence of valvular disease of the heart. Eed corpuscles 20 per cent., haemoglobin 10 per cent. Post-mortem examination.—Heart (16 ozs.) considerably en- larged, its muscle soft and pale, with the appearances of fatty degeneration. Numerous minute haemorrhages were found scattered throughout its substance. The mitral and tricuspid valves were thickened and deformed, evidently the result of chronic endocarditis. Minute haemorrhages found on the surface of the lungs. Liver (60 ozs.) hyperaemic, considerable fatty change in the hepatic cells. Kidneys much congested; both had appearances of commencing interstitial nephritis. Spleen (7 ozs) enlarged and dark red in colour. Numerous areas of congestion in alimentary tract; in caecum several small ulcers, each about the size of a millet seed. Considerable atrophy in the glandular epithelium of the stomach. Supra- renals and thyroid normal. Marrow from femur red in colour; microscopic appearances much the same as those in case 6. Deposit of iron pigment in liver very slight; absent in other •organs. Case 12. A. Z., act. 57. Died Jan. 22, 1892. A case of heart disease (mitral incompetence), of at least two years’ standing, following an attack of rheumatism. For some months before death signs of cardiac failure with increasing anaemia. Attacks of epistaxis frequent and a purpuric eruption was present on the legs. Eed corpuscles 24 per cent., haemo- globin 22 per cent. Post-mortem examination.—Subcutaneous fat abundant. Peri- cardium contained six ounces of clear serum. Heart (14£ ozs.) enlarged and its muscle tissue showed distinct signs of fatty degeneration. Liver (51 ozs.) pale, only slight fatty change in the hepatic cells. Spleen (4 ozs.), kidneys and suprarenal capsules were quite normal. Stomach enlarged; there was to be noted in its anterior a small ulcer which microscopic examination proved to be cancerous. Marrow from femur was a mass of yellow fat and contained none of