On the pathology of pernicious anaemia / by Walter K. Hunter, M.D., B.Sc.

  • Hunter, Walter King.
Date:
[1897?]
Catalogue details

Licence: Public Domain Mark

Credit: On the pathology of pernicious anaemia / by Walter K. Hunter, M.D., B.Sc. Source: Wellcome Collection.

Provider: This material has been provided by The University of Glasgow Library. The original may be consulted at The University of Glasgow Library.

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    and signs of fluid in both pleural cavities. Patient had suffered for twenty-six years from bleeding piles. Blood examined three weeks before death—red corpuscles 23 per cent., haemo- globin 25 per cent. Post-mortem examination.—Considerable serous effusion into pericardium, both pleural cavities and into abdominal cavity. Heart (16 £ ozs.) enlarged, external fat very much increased ; muscular tissue pale and flabby, having undergone considerable fatty degeneration. Lungs oedematous. Liver (441 ozs.) small and pale; considerable fatty degeneration of the hepatic cells. Spleen (2^ ozs.) quite normal. Kidneys, suprarenals, stomach and intestines also normal. Marrow from femur semi-fluid and red in colour; microscopic appearances similar to those described in case 5. Deposit of iron pigment in the liver, though quite distinct, was by no means abundant. It was more marked in the capillaries than in the hepatic cells, in which it appeared more as a diffuse stain than as a finely granular deposit. In the kidneys there was a distinct deposit in the epithelium of convoluted tubules ; practically none in any of the other organs. Case 9. J. M., act. 45. Died July 30, 1894. Case of anaemia of four years’ duration, characterized by progressive weakness, pallor, breathlessness, palpitation, oedema of feet and eyelids. Trace of albumin in urine. Patient had been subject to chronic bronchitis for twenty years. Blood examined shortly before death—red corpuscles 18'6 per cent., haemoglobin 20 per cent. Post-mortem examination.—Pericardium, left pleural cavity and abdominal cavity each contained several ounces of brown- coloured serum. Heart (lOi ozs.) soft and flabby, external fat increased, but muscle fibres free from fatty changes. Lungs oedematous. Liver (60 ozs.) showed moderate fatty degener- ation. Spleen (12 ozs.) much enlarged, soft, in structure quite normal. Both kidneys slightly enlarged, with slight increase of the connective tissue elements, suggesting a commencing interstitial nephritis. Bronchial lymphatic glands enlarged and the seats of minute extravasations of blood. Stomach showed atrophy in many of the gastric glands. Nothing special to note in pancreas, suprarenal capsules or thyroid