On the pathology of pernicious anaemia / by Walter K. Hunter, M.D., B.Sc.

  • Hunter, Walter King.
Date:
[1897?]
Catalogue details

Licence: Public Domain Mark

Credit: On the pathology of pernicious anaemia / by Walter K. Hunter, M.D., B.Sc. Source: Wellcome Collection.

Provider: This material has been provided by The University of Glasgow Library. The original may be consulted at The University of Glasgow Library.

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    Post-mortem examination.— Pericardium and left pleural cavity each contained several ounces of clear serum. Heart (12f ozs.) increased in size and external fat much greater than normal; muscle wall soft and pale and the seat of extensive fatty degeneration; valves and coronary arteries healthy. Lungs oedematous. Liver (70 ozs.) enlarged, with marked fatty degeneration especially at centres of lobules. Spleen (6i ozs.) soft, deep red in colour, malpighian corpuscles larger than normal. In intestine the solitary follicles near to ileo-colic valve unduly prominent. Glands of stomach slightly atrophied, with slight increase of the connective tissue round about them. Kidneys, suprarenals and pancreas all healthy. Marrow of femur reddish in colour and semi-fluid in consistence ; appear- ances microscopically similar to those in case 1. Here, however, there was possibly a slightly larger proportion of marrow cells. Deposit of iron pigment in liver considerable; more marked in hepatic cells than in capillaries. No deposit in any other organs. Case 6. Mrs. F., aet. 31. Died March 18, 1897. Case of profound anaemia of several months’ duration. History of increasing weakness, pallor, emaciation, dating from a confine- ment during which patient lost a considerable quantity of blood. On several occasions during the illness there were haemorrhages from the bowels. Blood examined a week before death—red corpuscles 16 per cent., haemoglobin 15 per cent., white corpuscles 1 in 44. Post-mortem examination.—Pericardium contained 3 ounces of clear serum. Heart (9 ozs.) soft and flaccid; its muscle presented appearances of fatty degeneration. Liver (61 ozs.) pale and soft; fatty degeneration in many of the hepatic cells, especially those at centres of lobules. Spleen (84 ozs.) con- siderably enlarged ; pulp packed with blood corpuscles. Mesenteric glands enlarged, soft and pale, but structurally quite normal. Kidneys, suprarenals, pancreas, stomach and intestines presented normal appearances. Marrow from femur salmon-coloured and semi-fluid ; microscopic appearances similar to those of case 5. Deposit of iron pigment in liver very slight, less marked in