Volume 3

Final report of the Royal Commission appointed to inquire into the relations of human and animal tuberculosis. Part II. Appendix. : 1.- Certain human viruses of irregular type. 2.- The excretion of tubercle bacilli in the milk of animals. 3.- Swine tuberculosis. 4.- Immunity.

  • Great Britain. Royal Commission on Tuberculosis (Human and Bovine)
Date:
1904-1913
Catalogue details

Licence: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

Credit: Final report of the Royal Commission appointed to inquire into the relations of human and animal tuberculosis. Part II. Appendix. : 1.- Certain human viruses of irregular type. 2.- The excretion of tubercle bacilli in the milk of animals. 3.- Swine tuberculosis. 4.- Immunity. Source: Wellcome Collection.

Provider: This material has been provided by London School of Hygiene & Tropical Medicine Library & Archives Service. The original may be consulted at London School of Hygiene & Tropical Medicine Library & Archives Service.

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    In the lower part of the intestine the ulcers were not so numerous nor so definite in outline, and appeared as superficial erosions. They usually involved the mucous membrane only, but in one or two cases the peritoneum was seen to be exposed in the centre of the ulcer. The Peyer's patches, except in the lower part, were severely affected, and in many the whole of the central part was eroded ; in others there were irregular serpiginous ulcers, often surrounding isolated islands of mucous membrane. The ulcers extended to the muscle wall, the substance of the patch appearing as if eaten away in these places. There was no thickening of the margins of the ulcers nor of the bases, and there was no surrounding congestion. In the patches in the lower part of the intestine they became less pronounced, and in the long terminal patch one saw merely a number of small irregular pits. Large Intestine. — The solitary lymphoid follicles were conspicuous, but not apparently enlarged ; they had an opaque white appearance, and their central openings showed a little larger than usual ; no ulcers were seen. Mesenteric Glands.—All the mesenteric glands were firm, and were two or three times their normal in size. On the surface they showed a faint whitish mottling. On section they showed creamy white streaks or whitish foci throughout their substance ; in some a kind of network was formed. lleo - colic Glands. — The ileo-colic glands were slightly enlarged, and contained a smaller number of streaks and foci. Colic Glands.—The colic glands were normal. Abdomen Peritoneum.—Normal. Liver.—In the substance of the liver, under the capsule, a pinhead-sized white spherical body was seen ; otherwise normal. Portal Glands.—Normal. Spleen.—Normal. Kidneys.—One kidney showed on the surface a grey point of doubtful nature. The other was normal. Suprarenal Bodies.—Normal. Tito rax. Lungs.—Normal. Bronchial Glands.—Normal. Mediastinal Glands.—Normal. Heart.—Normal. Pleura.—Normal. Peripheral Lymphatic Glands.—Normal. Testes.—Normal. Microscopical Examinations. (Smear preparations.) Scraping from Mucous Membrane of Small Intestine. —Moderate number of tubercle bacilli. Left Submaxillary Gland.—A few tubercle bacilli. Mesenteric Gland.—Numerous tubercle bacilli. Spleen ... ... ... ... - Liver ... ... ... ... Kidney ± No tubercle bacilli. Portal Gland... Lymphoid Follicle from Colon J CALF 318. Virus P III. Subcutaneous inoculation of culture derived from the original material. Dose—50 0 milligrammes. Date—September 7, 1905. Weight at Inoculation—97-90 kilos. [Age about 5£ months.] Killed when in good health—December 11, 1905. [95 days after inoculation.] Clinical Notes. Five days after inoculation on the left side of the neck a flattened thickening could be felt, and the adjacent prescapular gland was slightly enlarged. On the 15th day there was a slightly raised hard tumour measuring 14 by 10 cm. ; the prescapular gland was very large, 12-5 cm. in length. On the 23rd day both the tumour and the prescapular gland had shrunk a little. The calf which up to this time had been well, seem a little unwell and was quieter than usual. On the 55th day the tumour measured 9 by 7-5 cm., it was adherent to skin and subjacent muscle and appeared to be softening. The prescapular gland was 11*5 cm. in length ; the prepectoral gland was slightly enlarged. The general condition of the animal was now good. Subsequently one extremity of the left prescapular gland become soft and fluctuating. It increased in size and became adherent to the skin and finally (88th day) burst, discharging yellow pus ; the opening then became covered with a scab. The calf was quite well. No further change of importance took place in the local conditions. Temperature. (Chart to November 2.) ?£ 3D 5 P . . JS, , . . ■» ,*r. , . ft From November 2 to December 11, when the calf was killed, the temperature remained normal.