Study XXII : the effect of theobromin sodium salicylate in acute experimental nephritis, as measured by the excretion of phenolsulphonephthalein / Henry A. Christian, M.D., Boston.

  • Christian, Henry A. (Henry Asbury), 1876-1951
Date:
1914
Catalogue details

Licence: In copyright

Credit: Study XXII : the effect of theobromin sodium salicylate in acute experimental nephritis, as measured by the excretion of phenolsulphonephthalein / Henry A. Christian, M.D., Boston. Source: Wellcome Collection.

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    dence of any harmful action. Rather are the results suggestive of no constant action. SUMMARY So far as renal function may be judged from phenolsulphone- phthalein excretion in acute experimental nephritis produced by uranium in the rabbit, there is no evidence that theobromin sodium salicylate exerts any constant beneficial action. In the severer forms there is almost no evidence of beneficial action; in the very mild forms there is occasionally evidence of beneficial action, but this is too incon¬ stant to justify the conclusion that theobromin sodium salicylate really improves renal function even in the very mild forms of acute nephritis. As other experimental evidence (Christian and O’Hare4) has shown the injurious action of theobromin sodium salicylate in shortening the life of rabbits with severe acute experimental (uranium) nephritis, it would seem fair to conclude that there is considerable evidence against