Study XXII : the effect of theobromin sodium salicylate in acute experimental nephritis, as measured by the excretion of phenolsulphonephthalein / Henry A. Christian, M.D., Boston.

  • Christian, Henry A. (Henry Asbury), 1876-1951
Date:
1914
Catalogue details

Licence: In copyright

Credit: Study XXII : the effect of theobromin sodium salicylate in acute experimental nephritis, as measured by the excretion of phenolsulphonephthalein / Henry A. Christian, M.D., Boston. Source: Wellcome Collection.

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    well as by Series 1, it does not appear that theobromin sodium salicylate exerts any evident beneficial action on renal function as measured by phenolsulphonephthalein excretion; occasionally it seems to do good, but on the other hand, occasionally it seems to do harm. Consequently, it may be said that its use in rabbits with so severe an acute nephritis is a questionable therapeutic measure. Examination of the charts shows that diuresis, though common, is not constant under the conditions of these experiments, and that it may occur a few days after the uranium is given, whether or not a diuretic , 0.25 mg. per kilogram of body weight. B, theobromin salicylate, 14 mg. per kilogram. is used. What is quite striking is that urine output and renal function as measured by phenolsulphonephthalein excretion do not necessarily run parallel, and sometimes animals with marked diuresis die.* In these animals phenolsulphonephthalein output is distinctly a better prognostic sign than urine output. In Series 6 (Rabbits 789, 790, 791) and 7 (Rabbits 815-819) still smaller doses of uranium nitrate were used, 0.5 mg. per kilogram of body weight (for results See Charts 7, 8, 9 and 10 of illustrative ani- * None of the charts selected for printing from these series show this but it is shown in Charts 9 and 10 of the next series.