Biochemical studies of sulfocyanates ... / By Max Kahn.

  • Kahn, Max, 1887-1926.
Date:
1912
Catalogue details

Licence: Public Domain Mark

Credit: Biochemical studies of sulfocyanates ... / By Max Kahn. Source: Wellcome Collection.

Provider: This material has been provided by the Augustus C. Long Health Sciences Library at Columbia University and Columbia University Libraries/Information Services, through the Medical Heritage Library. The original may be consulted at the the Augustus C. Long Health Sciences Library at Columbia University and Columbia University.

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    Effect of Administration of Sodium Sulfide upon the Elimina- tion of Sulfocyanatcs, Two dogs whose excreta were analyzed daily for five and eleven days respectively were fed according to their weight with meat, lard, cracker meal, bone ash and water. Before beginning to administer the sulfide to these animals, an attempt was made to determine which dosage will produce the least amount of discomfort to the animals, and especially which dosage will not cause vomiting; for, when the sodium sulfide enters the stomach, it is acted upon by the hydro- chloric acid of the gastric juice and sulfuretted hydrogen is produced which will cause emesis. A third dog was taken and 0.5 gram sodium sulfide was given him in a gelatin capsule. He promptly vomited. Next day before feeding this dog a capsule containing 0.2 gram sodium sulfide was given. The dog licked up his food. After half an hour there was noticed marked eructation of hydrogen sulfide. The vomiting was very slight. It was decided, therefore, to use 0.15 gram of sodium sulfide for the dogs IX and X. On March 20, 1912, dogs IX and X were each given 0.15 gram sodium sulfide in gelatin capsules. They ate their food heartily and did not seem to suffer any discomfort. They were fed daily in like manner, 0.15 gram sodium sulfide for five days. The urine and feces were collected daily and analyzed for sulfocyanate. The daily urine and feces analyses are given in Table 7 and 8. Table 7.—Dog IX.—Weight 6.94 Kilos. Aim Date. Na2S given. Gram. Urine. Cc. KSCN in urine. Mg. Feces. Grams. KSCN in feces Mg. iar. 16 17 18 320l 340 2IO J 8-3 27 I 25 t 9-6 19 20 220 \ 250 j 5 5 24 1 27 \ 30 J 14 7 21 O I5 I90 2.9 35 7.2 22 O.I5 3IO 46 32 7-5 23 O.I5 370 4 4 30 7.8 24 O.I5 300 3 9 33 8.3 25 O.I5 220 4.2 29 8-5