Biopharmaceuticals are a very important part of the therapeutic options in many diseases. They are made by, or derived from, living organisms using biotechnology. But they are also very expensive drugs. Biosimilar are the generally cheaper versions of existing biopharmaceuticals that are made after the market exclusivity rights of the original biopharmaceutical has expired. They are properly licensed, with proven comparable quality, efficacy and safety.
The therapeutic window is not identical in all of us. The average therapeutic window is represented by the overlapping of many windows. The green coloured molecule near the top of the average window is the originator. The red background molecule is the first biosimilar. The other red one is the second biosimilar. The other green background molecule lower down is also the originator, after a manufacture change was implemented.
