Genetics for the clinician / C.A. Clarke.

  • Clarke, Cyril A. (Cyril Astley)
Date:
1964
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Licence: Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

Credit: Genetics for the clinician / C.A. Clarke. Source: Wellcome Collection.

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    THE NATURE OF THE GENE 7 Any substance which forms the heritable material must be stable, be able to hand on information, be capable of replication and able to mutate. DNA fulfils all these criteria. Thus (1) It will stand boiling for one hour. (2) Replication can be effected. Exactly how this is carried out is uncertain, but the generally accepted explanation is again that of Watson and Crick (1953)- They suggest that if the two chains which are wound round each other separate, each single cham will have a series of bases needing new 1 34 Л I I I I I I I I I I „ I I 20 A Figure 1.3. Diagram representing the double helix of DNA, giving dimensions in Angstrom units. The two ribbons symbolise the two phosphate-sugar chains and the horizontal rods the paths of the bases holding the chains together. The arrows show that the sequence of bases goes one way in one chain and the opposite way in the other. The vertical line represents the axis of the molecule.