Report on the outbreak of poliomyelitis during 1961 in Kingston-upon-Hull and the East Riding of Yorkshire.

  • Great Britain. Ministry of Health.
Date:
1963
Catalogue details

Licence: Public Domain Mark

Credit: Report on the outbreak of poliomyelitis during 1961 in Kingston-upon-Hull and the East Riding of Yorkshire. Source: Wellcome Collection.

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    respect from the character of the vaccine virus. Three gave good growth at 40°C. and were designated t+. Four showed slight growth at this tem- perature and were designated t+. In three instances several faecal speci- mens were collected at intervals from the same child. Table 27 shows the results of “t’’ marker tests on these specimens. Children A and B con- tinued to excrete virus of changed character. Child C was found to be excreting a virus of changed character on one occasion only and subsequent isolations had ithe properties of the vaccine virus. This phenomenon has been described by Dick and Dane (1957) and by Sabin (1959). Fourteen strains of Type 2 poliovirus isolated from vaccinated individuals in Kingston-upon-Hull were found to be unchanged from the original vaccine virus in “t” marker tests. The specimens were collected one week after vaccination. Serological Investigations Five weeks after the vaccination campaign specimens of blood were obtained from persons who had been given oral vaccine but had not received Salk vaccine. Time did not permit the collection of specimens before vaccination. Table 28 Neutralizing antibody levels in Salk negative individuals 5—6 weeks after feeding type 2 vaccine Titre Type 2 antibody Age No. 10 or less 10 to 100 100 to 500 | 500 to 1,000} More than 1,000 0-6months... 1 — — — — 1 —2 years... 14 o— 1 3 1 9 —S years... 16 om whe Sed 4 4 6 -10 years ... | 20 aga — — y) 17 —15 years ... 27 — aa — 1 26 Over 15 years 11 — — 1 1 9 Total 1.2, ah Lay) 3/(3°3) 8 (9:0) 910-1) 68 (76-4) (Percentage of total in brackets.) Table 28 shows the titres of Type 2 antibody which were found after vaccination. ‘Titres of 10 or more were obtained in 88/89 (98-9 per cent) and of 100 or more in 85/89 (95:5 per cent). These high proportions can be interpreted as due in part to naturally acquired antibodies and in part to the effect of vaccination. It was not possible to assess the antibody responses to vaccination alone.