General and local anesthesia / by Aimé Paul Heineck.

  • Heineck, Aimé-Paul, 1870-1958.
Date:
1901
Catalogue details

Licence: Public Domain Mark

Credit: General and local anesthesia / by Aimé Paul Heineck. Source: Wellcome Collection.

Provider: This material has been provided by the Augustus C. Long Health Sciences Library at Columbia University and Columbia University Libraries/Information Services, through the Medical Heritage Library. The original may be consulted at the the Augustus C. Long Health Sciences Library at Columbia University and Columbia University.

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    doses in excess of the therapeutic dose, they are liable to cause annoying accidents. j HOLOCAINE. ' Holocaine is the ideal local anesthetic for re- moving foreign bodies from the conjunctival sac/' j (Knapp.) Holocaine is freely soluble in boiling j water, but sparingly in cold water. It is neutral | in reaction. Having germicidal properties, solu- \ tions of holocaine do not need sterilization. Boiling does not change it chemically or reduce its efficacy, but as a 1% solution is decidedly bactericidal^ i sterilization by heat is unnecessary. (Louis C. j Dean.) In making solutions of holocaine, dissolve ^ the latter in a porcelain vessel, as it causes glass ' containing alkali to lose a portion of the latter. ] This clouds the solution. Holocaine is a stable j agent. A 1 % solution will remain clear for about ; two months. ''■ Applied to mucous membrane, it produces no j constitutional symptoms. Administered suj)cu- i taneously, it is a poison. No poisonous effect from j the local use of the drug has ever been reported. j The toxic dose of holocaine when administered '. subcutaneously or internally, is oue centigramme. Holcaine is used extensively in ophthalmic prac- tice. It has been found to be an efficient local | anesthetic in eye surgery. It seems to act by pro- • i ducing a paralysis of the sensory nerve endings. j