Primary cancer of the lung / by J.H. Musser.

  • Musser, John Herr, 1856-1912.
Date:
[1903]
Catalogue details

Licence: In copyright

Credit: Primary cancer of the lung / by J.H. Musser. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

    15/22 (page 13)
    masses completely filling alveolus. In more com- pact portions of tumor the cells lining the alveoli may assume a cylindrical shape. In these earlier portions of the tumor the only stroma is that of the normal framework of the lung. Alveoli along advancing edge not filled with tumor cells contain granular and disintegrated desquamatedcells. In older portions of tumor the arrangement of the tumor is distinctly papillary, the cells somewhat cylindrical, and the stroma increased in amount. At first glance this portion of tumor seems to bear no relation to the earlier portion, but on careful study it is seen that the stroma and the bloodves- sels bear a close resemblance to the normal inter- alveolar wall. The papillary processes can, in nearly all instances, be shown to lie in spaces, their point of origin being from cells lining the stroma. The picture is, therefoi’e, one of prolifera- tion of cells lining the alveoli, the proliferating cells assuming, owing to the restraint under which they ai’e placed by the limiting alveolar wall, a papillary arrangement and filling the alveolar space. As a result of the increased demand of this new tissue for nutrition, a greater vascularization of the alve- olar wall has occurred with corresponding increase in stroma. The occasional presence of carbon pig- ment in the stroma is evidence that the stroma is not entirely a new-formation. The epithelium lining bronchi of all sizes is intact. The mucous glands show no deviation from normal. In loose tissue about the lymphatic spaces of the bronchi the extension of the tumor is seen in the form of a tubular arrangement of the epithelial cells entirely distinct from the cylindrical cell of