Observations in four cases of chronic dysentery non-amebic in nature / by Anthony Bassler.

  • Bassler, Anthony, 1874-
Date:
1911
Catalogue details

Licence: In copyright

Credit: Observations in four cases of chronic dysentery non-amebic in nature / by Anthony Bassler. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    being charged with them, and in the ulcer scrapings it was shown that these organisms had gained en- trance into the tissue walls of the gut and were living and probably proliferating there. Scrapings from the mucous membrane of the upper rectum and colon in seven healthy persons did not show the presence of the B. coli communis within the tis- sue of the gut wall when proper precautions had been exercised in the scrapings. In each of the cases the organisms grown in culture were Gram negative, flagella were noted in the form from one (not from the other three), they were non-liquefy- ing, grew readily on all of the culture media (and characteristically in large opaque colonies on the gelatine and most abundantly on potato), produced organic acids in milk, fermented glucose solutions with the production of acid and gas, and did not produce indol in ordinary nutritive broth (two of them did in Witte peptone solution), and the in- traperitoneal injections of the bacteria grown from all of the cases were fatal within four days to a rabbit, guinea-pig, and cat in each instance—all of the animals dying within 50 hours, excepting a cat, which lived 93 hours. It was this definite pathogenesis in lower animals (in which it was evident that these organisms were more regularly fatal than is one’s experience with the usual forms of B. coli communis) that sug- gested the making of agglutinating reactions with the serum and organisms from the cases with con- trols of those of other strains in the hope that some facts might be gained in identifying the type of organism at work in the condition. In each in- stance it was found that the serums from these in- dividuals agglutinated their own strain of organ- isms more definitely than they did the B. coli com- \