The treatment of sarcoma and carcinoma by injections of mixed toxins / by C. Mansell Moullin.

  • Mansell-Moullin, C. W. (Charles William), 1851-1940.
Date:
1898
Catalogue details

Licence: Public Domain Mark

Credit: The treatment of sarcoma and carcinoma by injections of mixed toxins / by C. Mansell Moullin. Source: Wellcome Collection.

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    A portion removed for microscopic examination was proved to be spindle-celled sarcoma. Injections were commenced on October 31, 1893. ^^^^ filtered cultures of the erysipelas coccus only were used. As the dose increased the toxins formed by the bacillus pro- digiosus were added. The injections were given in various parts of the body, and generally caused pain, redness and swelling. There was usually a rise of temperature with a feeling of chilliness, and sometimes a very violent rigor, with- out its being possible to offer a reason for the difference. One chill was so violent and followed by such serious symp- toms, that the patient was confined to bed for a fortnight and all treatment stopped. A peculiar attack of keratitis developed at the end of five months. This also caused an interruption in the treatment for three weeks. The result was a steady but slow improvement. In two weeks the soreness left the throat and he was able to swallow solids as well as fluids. The granular masses disappeared, some by necrobiosis, others by absorption, and the patient's weight increased from eighty-six pounds to one hundred and seven. No injections were made after June. In October, 1894, there were only one or two spots of ulceration; cicatrisation and contraction had taken place and white bands of adhesion extended from the hard palate to all parts of the fauces. In September, 1896, the patient was perfectly well, and there was no sign of any recurrence. CzERNY {Munch. Med. Woch., September 3, 1895, No. 36, p. 833) made use of toxins prepared by Werner and Petersen. The streptococcus from a case of erysipelas was cultivated in bouillon for three weeks, mixed with the bacillus pro- digiosus and sterilised at 58° C. The dead bodies were not separated by filtration. The patient was a woman aged 35. During pregnancy a swelling had made its appearance in the right parotid region. This had grown rapidly and had made its way into the meatus, fungating through the skin and causing facial paralysis. Behind the ear there was a mass the size of a large fist, and the soft structures around were infiltrated for