The treatment of sarcoma and carcinoma by injections of mixed toxins / by C. Mansell Moullin.

  • Mansell-Moullin, C. W. (Charles William), 1851-1940.
Date:
1898
Catalogue details

Licence: Public Domain Mark

Credit: The treatment of sarcoma and carcinoma by injections of mixed toxins / by C. Mansell Moullin. Source: Wellcome Collection.

    18/72 (page 16)
    in outline until there was very little of it to be felt. Since then it has scarcely altered. (2) F. D., aged 48, was admitted into the London Hospital on November 10, 1896, for an abdominal tumour. One month before, patient had been seized with a sharp pain in the left flank. Shortly afterwards he noticed that there was a swelling there. He had been constipated of late, and had suffered much from flatus. There were no urinary symptoms. On examination the left flank was occupied by a large swelling of irregular shape, hard, not fluctuating, and not connected with the skin or the abdominal muscles. It ap- peared to be fixed. Below it descended into the iHac fossa. Above it reached under the false ribs. In front it came nearly to the middle Hue, pushing the colon in front of it. There was no glandular enlargement, and very little pain. D uring his stay in the hospital the tumour enlarged rapidly. Patient went out and was re-admitted on December 12. The tumour had increased considerably in size, but there was less trouble with the bowels. On December 14, half a minim of Coley's fluid was in- jected over the tumour, and the temperature rose that evening to 100° F. On the i6th, two minims were injected, and the injections were continued every two or three days, the amount being increased gradually to six minims. As a rule there was no rise of temperature. On December 29, however, when four minims were used, there was a rigor with a temperature of 102^^ F. On January 24, seven minims were injected. The same evening the temperature rose to ioi-8°, and the patient complained of headache, cold shivers, sweats and throbbing. The next day, without anything further being done, it rose again to 103-6°, and for a fortnight it continued very irregular, and persistently above normal. No further injections were made. The tumour continued to increase in size until at last it pressed upon the colon to such an extent that obstruction seemed imminent. At the time of the rigor in the middle of January it became acutely inflamed, the skin being red and oedematous, so that there was some fear of suppuration setting in. Under the influence of rest and lead lotion this slowly subsided, and after the inflammation had gone the shrinkage continued until scarcely anything of the original swelling could be felt.