Materia medica, pharmacology and therapeutics : inorganic substances / by Charles D.F. Phillips.

  • Phillips, Charles D. F. (Charles Douglas Fergusson), 1830-1904.
Date:
1904
Catalogue details

Licence: Public Domain Mark

Credit: Materia medica, pharmacology and therapeutics : inorganic substances / by Charles D.F. Phillips. Source: Wellcome Collection.

Provider: This material has been provided by the Francis A. Countway Library of Medicine, through the Medical Heritage Library. The original may be consulted at the Francis A. Countway Library of Medicine, Harvard Medical School.

    87/988 (page 67)
    The two remedies are, doubtless, allied, but the former is more trustworthy. Preparations and Dose.—Phosphoruf;-. dose,T^to^Vgr., or less (g^), Oleum phosplioratum (made with oil of almonds) contains 1 per cent, by weight of phosphorus : dose, 1 to 5 min. Pilula pJiosphori (1 in 90): dose, 1 to 2 gT. in pill. Zinci phosphidum : dose, ^V to ^ gr. in pill, with sugar of milk, and glyc. trag. (not off.); calcii hypophospMs : dose, 3 to 10 gr.; calcii phosplias: dose, 5 to 15 gr.; sodii hypopJiosphis: dose, 3 to 10 gr. (v. Calcium and Sodium). These may be given in solutioa in syrup, in cod-liver oil, or in mixtures. Exception has been taken to the oil as disagreeing with the stomach,^ to the jjiZZ as being too concentrated, or not soluble enough: and many other formulae for the medicine have been pubhshed (B. M. J., i., 1879; v. Martindale's article on pills,, B. M. J., i., 1902). It is commonly agreed that the free unoxidised element will produce effects which none of its. chemical compounds can do, and it is desirable, therefore, ta give it in its pure unaltered state. An alcoholic tincture may be prepared by adding phosphorus, in excess to boiling alcohol quite free from water; this will take up 1 gr. in 6 dr. 20 min. (Thompson), and, if carefully kept from light and au\ will remain unchanged for some weeks : 3 dr. 10 min. of this tincture (= ^ gr. phosphorus) added to 1 oz. 40 min. of anhydrous glycerin, with 5 min. of spirit of peppermint, is a stable and not disagreeable form. I myself prefer an ethereal tincture, in which 1 gr. phosphorus is first dissolved in 1 dr. of pure ether; and this solution, after standing some days, is mixed with pure alcohol, so that a pro- portion of 1 gr. in 500 min. is preserved. From 2^ to 5 or 10 min. of this {-^jj to yig- or ^l gr.) are readily taken, mixed with water, and the preparation is stable enough for all practical purposes, though it should not be kept long. There is a compound tincture of alcohol and chloroform con- taining 1 gr. in 600 (dose 3 to 12 min.) and an ehxir of the same with glycerin containing Jg- gr. in 1 dr. (B. P. C.) : (dose 15 to 60 min.). There is also a good French syrup (Fauconnet). ^ A medical man in France recently was fined for the death of a boy to whom he had given this oil with cod-liver oil: vomiting occurred after six doses, then jaundice, pain, delirium and death : the liver was fatty and phosphorus poisoning was presumed (Hale White).