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Translocation - use of cosmid probe

Wessex Reg. Genetics Centre

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Credit: Translocation - use of cosmid probe. Credit: Wessex Reg. Genetics Centre. Attribution 4.0 International (CC BY 4.0)

About this work


Human chromosomes at metaphase, highlighted by fluorescent probes that bind to specific base sequences on the DNA. This cell has a translocation between the X chromosome and a chromosome 13 (X;13). The cosmid probe from the XIST region (red) has not been disrupted by the Xq break point. The use of such probes can help to determine the break-points in the translocation. (See also B0000313C) Image by Dr John Crolla.


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