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Translocation - use of cosmid probe

Wessex Reg. Genetics Centre

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Credit: Translocation - use of cosmid probe. Credit: Wessex Reg. Genetics Centre. Attribution 4.0 International (CC BY 4.0)

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Human chromosomes at metaphase, highlighted by fluorescent probes that bind to specific base sequences on the DNA. This cell has a translocation between the X chromosome and a chromosome 13 (X;13). The cosmid probe from the XIST region (red) has not been disrupted by the Xq break point. The use of such probes can help to determine the break-points in the translocation. (See also B0000313C) Image by Dr John Crolla.

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