The genetic basis of development / Alistair D. Stewart and David M. Hunt.

  • Stewart, Alistair D.
Date:
1982
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Licence: Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

Credit: The genetic basis of development / Alistair D. Stewart and David M. Hunt. Source: Wellcome Collection.

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    Despite the fact that the regulation of gene expression is cited as the fun¬ damental mechanism in development, student courses in developmental biology frequently do not truly reflect the significance of genetic variation and genetic control at all levels of development. This book is written with the aim of increasing the reader's awareness of the contribution which genetical knowledge can make in understanding developmental pro¬ cesses. It also stresses the advantage of an interdisciplinary approach to developmental biology, especially by geneticists, biochemists, and embry- ologists. Throughout the book there is a strong emphasis on the description of genetic systems, and scientific experiments are evaluated in the context of the major current concepts in the field. These experiments have been carefully chosen to illustrate a range of organisms, while still maintaining con¬ tinuity from one chapter to the next. The final chapter, on sexual differentia¬ tion in mammals, is designed as a small case study to link together the inter¬ relationships between mechanisms acting at different levels of organiza¬ tion, which have all |been discussed separately in preceding chapters. Although intended principally for students following courses in developmental genetics, the book will also provide a refreshing perspective on developmental processes for students in biology, zoology, and biochemistry who have a basic knowledge of eukaryotic genetics. The authors hope, too, that their book will foster an appreciation, among lecturers and researchers, of the importance of genetic mechanisms in the study of developmental biology. Contents: ] Preface j Introduction j The constancy of the genome ( Cytoplasmic regulation of gene' expression during development ( The molecular biology of chromatin! and nucleic acids Genetic studies of regulation in) higher organisms Gene interactions in development ! Intercellular interactions in development} Sexual differentiation in mammals Bibliography j Index The Authors 1 Alistair Stewart began his university! career at the University of Cambridge,] with a degree in genetics, and he remained at Cambridge for his doctoral studies. After some time in a teaching post at the University of Edinburgh, Dr Stewart was appointed lecturer at thei University of Lancaster, where he organised the teaching of developmental genetics. Recently, Alistair Stewarti moved to the University of Leeds. He has had experience of teaching in the United States, as a visiting lecturer in the University of California, at both Berkeley and San Francisco. David Hunt is Lecturer in Genetics at Queen Mary College, University of London. Before being appointed to his present post he was lecturer at the University of Glasgow, and before that was, for 5 years, a research assistant at the Medical Research Council's Experimental Genetics Research Unit at University College, London. Dr Hunt's first degree and doctorate are from the University of Sheffield. ISBN 0 216 91160 5