Find thousands of books, manuscripts, visual materials and unpublished archives from our collections, many of them with free online access.
Search for free, downloadable images taken from our library and museum collections, including paintings, illustrations, photos and more.
Shigella flexneri invading embryonic stem cell
- David Goulding, Wellcome Trust Sanger Institute
Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
You can use this work for any purpose, as long as it is not primarily intended for or directed to commercial advantage or monetary compensation. You should also provide attribution to the original work, source and licence.
Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) terms and conditions https://creativecommons.org/licenses/by-nc/4.0
Selected images from this work
About this work
Shigella flexneri is the causative agent of human shigellosis via the faecal-oral route, typically resulting in dysentery. Shigella invades through microfold (M) cells in the host gut in humans and primates solely. This scanning electron micrograph was produced as part of a research project using genetically modified embryonic stem cells to study Shigella-host interactions. The image demonstrates that after long filopodia from the host cell establish contact with the bacteria, actin-rich cell membrane ruffles are formed which envelope and engulf the Shigella. This process is actively orchestrated by the bacterium itself using the type III secretion system. The Shigella cell in center is 5µm long.