Interfacial forces and phenomena in physiology : being the Herter lectures in New York in March, 1922 / by Sir William M. Bayliss; with seven diagrams.

Bayliss, William Maddock, Sir, 1860-1924.

Date:: [1923]

Credit: Interfacial forces and phenomena in physiology : being the Herter lectures in New York in March, 1922 / by Sir William M. Bayliss; with seven diagrams. Source: Wellcome Collection.

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$carbon dioxide. But if we accept the value given to the acidic dissociation constant of haemoglobin, it can be calculated that only a small fraction of the sodium is com- bined at any time with haemoglobin, about 5 per cent., the rest being present as bicar- bonate. Further, recent experiments show that the contents of the red corpuscles are more acid than the plasma, and this would imply even less sodium in combination with haemoglobin. It is to be admitted that the above calculation rests on uncertain assumptions as to the effective molecular weight and concentration of haemoglobin, while the mode of deducing the acidic dissociation constant may not be correct where colloids are concerned. Oxyhaemoglobin is further stated to be a much stronger acid than reduced haemo- globin and thus capable of driving out carbon dioxide from bicarbonate in the lungs. But the chief evidence rests on measurements with the hydrogen-electrode and the differences found are within the errors said by S0rensen to be inherent in$