The chemistry of the jaborandi alkaloids / by H.A.D. Jowett. The pharamacology of the jaborandi alkaloids / by C.R.Marshall. Remarks on extractum jaborandi liquidum (B.P.) / by H.A.D. Jowett and C.R. Marshall.

  • Jowett, H. A. D. (Hooper Albert Dickinson)
Date:
1900?]
Catalogue details

Licence: In copyright

Credit: The chemistry of the jaborandi alkaloids / by H.A.D. Jowett. The pharamacology of the jaborandi alkaloids / by C.R.Marshall. Remarks on extractum jaborandi liquidum (B.P.) / by H.A.D. Jowett and C.R. Marshall. Source: Wellcome Collection.

    9/18 (page 7)
    In all experiments the nitrates of the alkaloids were em¬ ployed, but in all cases the dose is given as pure alkaloid. In the experiments on myself the substances dissolved in water were taken by the mouth. My endeavour was to obtain the least dose causing salivation and perspiration ; and under the conditions of the experiment this was obtained by pilocarpine 0.005 gram, isopilocarpine 0.04 gram, jaborine (Merck) 0.09 gram. Pilocarpidine 0.38 gram (4 grs.) did not produce distinct salivation or sweating, but it caused slight nausea. It may also be said that the resin of jabcrandi in doses of 2 grams (31 grs.) is inactive. Certain derivations of pilocarpine have been investigated, but these are of no practical interest, and their action will therefore be described elsewhere.