A laboratory course of pharmacy and materia medica : including the principles and practice of dispensing adapted to the study of the British Pharmacopoeia and the requirements of the private student / by William Elborne.

  • Elborne, William.
Date:
1890
Catalogue details

Licence: Public Domain Mark

Credit: A laboratory course of pharmacy and materia medica : including the principles and practice of dispensing adapted to the study of the British Pharmacopoeia and the requirements of the private student / by William Elborne. Source: Wellcome Collection.

    104/342 (page 86)
    hot, wash the charcoal with an additional 10 c.c. of boiling spirit, and set the filtrate aside for two days in a cool dark place to crystallise. Separate the mother-liquor from the crystals, and con- centrate to obtain a further product. Collect the crystals, let them drain, redissolve them in boiling spirit, and let the solution crystallise as before. Lastly, dry the crystals on filtering-paper in the dark, and preserve them in a bottle protected from light. VI. Assay 20 grms. of Belladonna Root for Alkaloids— Hyoscyamine and Atropine. Twenty grams of the dry and finely-powdered root are exhausted by hot percolation with a mixture of equal parts by volume of chloroform and absolute alcohol; if an extraction apparatus is used about 60 c.c. of the mixture is required. The percolate is agitated with two successive 25 c.c. of distilled water, which are separated in the usual way (the water withdraws spirit accompanied with alkaloids —the author). These are mixed and well agitated with chloroform to remove the last traces of mechanically adherent colouring matter. The chloroform is separated, the aqueous liquid rendered alkaline with ammonia and agitated with two successive 25 c.c. of chloroform, which are separated, mixed, and agitated with a small quantity of water (rendered faintly alkaline with ammonia) to remove adherent aqueous liquid. The chloro- form is then evaporated over a water-bath until the weight of the atropine and hyoscyamine is constant, which usually occupies a little less than one hour (Dunstan and Eansom, Fharm. Jour. (3), vol. xiv. p. 625). VII. Assay 250 grms. of Aconite Root for Aconitine (Aconitia Ph. B.). Reduce the root to coarse powder, mix with twice its weight of alcohol sp. gr. -838, and apply heat until ebullition commences; then cool and macerate for four days. Transfer the whole to a displacement apparatus, and percolate, adding more spirit, when requisite, until the root is exhausted (alkaloidal salt, resin, and colouring matter extracted). Distil off the greater part of the spirit from the tincture, and evaporate the remainder over a water-bath until the whole of the alcohol has been dissipated. Mix the residual extract thoroughly with twice its weight of boiling distilled water, and when it has cooled to the tempera- ture of the atmosphere, filter through paper (resinous matter left behind). To the filtered liquid add solution of ammonia in slight