The measurement of the combining power of diphtheria toxin and toxoid with anti-toxin in relation to their antigenic efficacy / by A.T. Glenny, C.G. Pope, and Hilda Waddington.

  • Glenny, A. T.
Date:
[1925?]
Catalogue details

Licence: In copyright

Credit: The measurement of the combining power of diphtheria toxin and toxoid with anti-toxin in relation to their antigenic efficacy / by A.T. Glenny, C.G. Pope, and Hilda Waddington. Source: Wellcome Collection.

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    addition of different amounts of antitoxin to a fixed volume of toxin. Chart 3 has heen prepared from the L4-, Lo, Lr and Lf values of the various modifications of toxin given in table III. to connect residual toxicity with the amount of toxin added to 1 unit of antitoxin. The curve of J 3485 can be visualised as built up from tigures like those given in table I. working from left to right along the table. Each curve can be regarded as a “ mirror image ” of the corresponding curve in chart 2, | These curves show that no free toxin exists until more than the Lf j dose of toxin has been added to 1 unit of antitoxin. If more toxin is i added some small quantity of specific toxin may be free but until the | Lr dose is reached the amount free is not enough to produce a reaction i when injected intracutaneously into a guinea-pig. This form of curve i affords a convenient method of showing the course of neutralisation within the differential region. Ehrlich used this phase to indicate the region between Lo and L-j- but we extend the phase to cover the range from Lf to L-f-. It appears that it is reg,sonable to suggest that the I