Diffuse sclerosis (encephalitis periaxialis diffusa) / by L. Bouman ; with 64 illustrations.

  • Bouman, L. (Leendert), 1869-1936.
Date:
1934
Catalogue details

Licence: In copyright

Credit: Diffuse sclerosis (encephalitis periaxialis diffusa) / by L. Bouman ; with 64 illustrations. Source: Wellcome Collection.

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    inertly when lifted up. The abdominal reflexes could not be evoked, but the tendon reflexes of the lower limbs were normal. Babinski’s sign was obtained on the left side but not on the right. The head and eyes were turned towards the left, and there were slight convulsions of the left arm. The patient was very drowsy and moaned continually. Jan. 5.—The patient had fifty-two fits. Jan. 6.—Only two slight seizures ; comatose. Jan. 7.—Stationary coma ; when the lips were touched the patient opened his mouth widely. Jan. 9.—Died. Pathological Examination.— Macroscopical Anatomy.—Even to the naked eye there appeared a surprising similarity to the changes found in Case I. Here, too, %% m * Fig. 5.—Case II. Slight perivascular infiltration around a vessel in the fifth layer of the cortex. (Weigert-Pal stain.) the changes occupied almost the entire white matter oi both hemi¬ spheres, and they appeared to be more severe, for the affected tissue was more gelatinous. Histopathology.—Compared with Case /, a considerably larger number of myelin sheaths were preserved, and the flbrte arcuatse were intact also. The number of vessels was not increased and they were not infiltrated, with the exception of some of the vessels on the margin of the diseased area, round which there were connective-tissue nuclei and lymphocytes {Fig. 5). This points to a difference between the centre and periphery of the areas of disease.