Congenital orbital sarcoma of endothelial origin in an infant : operation and preservation of globe / by Mortimer Frank.

  • Frank, Mortimer, 1874-1919.
Date:
[1903?]
Catalogue details

Licence: In copyright

Credit: Congenital orbital sarcoma of endothelial origin in an infant : operation and preservation of globe / by Mortimer Frank. Source: Wellcome Collection.

Provider: This material has been provided by UCL Library Services. The original may be consulted at UCL (University College London)

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    ful. This was probably due to the alcoholic fixation or to the slow growth of the tumor, as shown by the clinical course. In some of the alveolar spaces the cells have undergone degeneration. The cellular territories just described are bounded by tracts of connective tissue which, although not abundant, really form the structural framework of the tumor. This basement membrane, varying in thickness, forms a network with wide and irregular meshes in which the cellular elements lie. With Unna's poly- chrome methyl blue the connective tissue element stands out conspicuously, and while the cells within the alveolar spaces have but few fibers between them, it can readily be seen that at the circumfer- ence the covering cells are supported by bands of interstitial tissue carrying numerous blood-vessels. The stroma consists of loosely arranged fibers, with long, spindle-shaped or oval nuclei. Between these fibers are gaps and spaces which are occupied by red blood cells and occasionally by a few of the tumor cells. Within the stroma are seen vessels lined by a single layer of cells, identical with the tumor cells of the alveoli, representing a process of lymphangi- ectasis in which, as yet, no cell proliferation has occurred. Whether these be blood or lymph ves- sels, they seem to be conclusive proof that the growth is of mesodermic origin. The alveolar masses de- scribed above represent a proliferation of either blood or lymph vessel endothelium, and where they have coalesced, this proliferation has broken through its normal boundaries, in consequence of which a general invasion of the cells has occurred. Those portions of the neoplasm that contain the typical and well-marked alveolar structure lined with the double row of cells, which are probably dilated lymph vessels (lymphactasia), might suggest adenoma were it not that the development of these tubular structures forms an almost complete and