DNA-protein interactions / Andrew Travers.

London ; New York : Chapman & Hall, 1993.

vii, 180 pages : illustrations ; 24 cm

1st ed.

Copy 1 Donor: Wellcome Trust Sanger Institute.

DNA structure -- Structural features of DNA -- DNA polymorphism -- Conformational variability of DNA -- Intrinsic bending of DNA -- DNA supercoiling and topology -- Topology of protein-bound DNA -- Structure of supercoiled DNA -- DNA-protein interactions: the three-dimensional architecture of DNA-protein complexes -- General principles -- Local DNA conformation and protein binding -- DNA wrapping -- DNA configuration and sequence periodicity -- Establishment of DNA architecture -- DNa-protein interactions: sequence specific recognition -- General principles of sequence specific recognition -- Structural motifs for sequence specific binding -- Helix-turn-helix motif -- C₁ and cro repressors -- Catabolite activator protein (CAP) -- lac repressor protein -- Tryptophan repressor -- Zinc-containing DNA-binding domains the interaction of zinc fingers with DNA -- Other DNA binding structures -- Heterodimer formation -- Co-operative binding to DNA -- Co-operativity at a distance: DNA looping -- Protein flexibility in DNA-protein complexes -- Mechanism of RNA chain initiation -- Promoter -- RNA polymerases.

(cont) Kinetics of transcription initiation -- Molecular interactions of RNA polymerase with a promoter site -- Topological consequences of transcription -- Transcriptional activators -- Transcriptional activation by negative superhelicity -- How does RNA polymerase melt promoter DNA? -- Regulation of promoter selectivity in eubacteria -- Control of stable RNA synthesis -- Stable RAN promoters -- Transition from exponential growth to stationary phase and vice versa -- Sigma factors and promoter recognition -- Heat shock response -- Target for transcriptional enhancers -- Transcriptional programmes of bacterial viruses -- Mechanism of eukaryotic transcription -- Eukaryotic transcriptional regulatory elements -- Eukaryotic transcriptional regulators: structure -- Specificity and selectivity of eukaryotic transcription factors -- Sp1 transcription factor -- Heat shock transcription factor (HSF) -- How do transcriptional activators work? -- Transcription by RNA polymerase III -- Establishment of repression -- Chromatin and transcription -- Local control of chromatin structure -- Structural organization of chromatin -- Chromosomal superstructure -- Heterochromatin -- Regulation of transcriptional competence.

Includes bibliographical references and index.