The child with Down's syndrome (mongolism) : causes, characteristics and acceptance ; for parents, physicians and persons concerned with his education and care / David W. Smith and Ann Asper Wilson.

  • Smith, David W., 1926-1981.
Date:
[1973], ©1973
Catalogue details

Licence: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

Credit: The child with Down's syndrome (mongolism) : causes, characteristics and acceptance ; for parents, physicians and persons concerned with his education and care / David W. Smith and Ann Asper Wilson. Source: Wellcome Collection.

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    Chapter 1 Formation of a Translocation Chromosome r\ W 14 breaks ^ réarrangé 14 /21 TRANSLOCATION CHROMOSOME #21 pair of 21 chromosomes ^^ Triple dose of Double dose of 21 chromosome genes 21 chromosome genes ♦ ♦ TRANSLOCATION BALANCED NORMAL DOWN'S SYNDROME TRANSLOCATION CARRIER Figure 8. Formation of a translocation chromosome by breakage and rejoining of the major parts of two chromosomes into a single translocation chromosome (with the loss of the tiny broken pieces]. When the fertilized egg receives this 14/21 translocation chromosome plus the usual two 21 chromosomes, the result will be a baby with trans¬ location 21 trisomy Down's syndrome. When the fertilized egg receives the 14/21 translo¬ cation chromosome plus one 21 chromosome, the result will be a normal balanced translocation carrier, who will have a significant risk of having a child with Down's syndrome.