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The bronchial epithelium in disease.

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About this work


Here, Professor Lynne Reid from the Cardiothoracic Institute, University of London, talks about the bronchial epithelium. A summary accompanying the cassette reads: "Bronchial submucosal gland hypertrophy, together with increase in the number of goblet cells in the surface epithelium and their extension into peripheral airways, are the hallmarks of the human chronic bronchitis. Similar changes in mucus-secreting tissues, as well as increase in the number of cells in mitosis, can both be produced by a variety of irritants although not necessarily to the same degree. These tests offer two methods of 'titrating' epithelial damage. Recently it has been shown that isophrenaline and pilocarpine also produce similar changes but probably because of a different intracellular effect. Recent demonstration of nerve fibres within the bronchial epithelium, some at least motor in type suggests that both epithelial and submucosal glands are under nervous control."


London : University of London Audio-Visual Centre, 1971.

Physical description

1 encoded moving image (33.38 min.) : sound, black and white



Copyright note

University of London

Terms of use

Creative Commons Attribution-Non-Commercial 2.0 UK: England & Wales

Language note

In English

Creator/production credits

Presented by Professor Lynne Reid, Institute of Diseases of the Chest, University of London. Introduced by Dr Ian Gilliland. Produced by Peter Bowen. Made by University of London Audio-Visual Centre. Made for British Postgraduate Medical Federation.


This video is one of around 310 titles, originally broadcast on Channel 7 of the ILEA closed-circuit television network, given to Wellcome Trust from the University of London Audio-Visual Centre shortly after it closed in the late 1980s. Although some of these programmes might now seem rather out-dated, they probably represent the largest and most diversified body of medical video produced in any British university at this time, and give a comprehensive and fascinating view of the state of medical and surgical research and practice in the 1970s and 1980s, thus constituting a contemporary medical-historical archive of great interest. The lectures mostly take place in a small and intimate studio setting and are often face-to-face. The lecturers use a wide variety of resources to illustrate their points, including film clips, slides, graphs, animated diagrams, charts and tables as well as 3-dimensional models and display boards with movable pieces. Some of the lecturers are telegenic while some are clearly less comfortable about being recorded; all are experts in their field and show great enthusiasm to share both the latest research and the historical context of their specialist areas.


Segment 1 Gilliland introduces Reid. Reid shows a model of the bronchial tree and introduces the subject of chronic bronchitis. He shows a diagram of a 3-dimensional model of the bronchial sub-mucosal gland. Time start: 00:00:00:00 Time end: 00:05:19:00 Length: 00:05:19:00
Segment 2 Reid describes how, in chronic Bronchitis, the sub-mucosal glands are enlarged. He shows diagrams comparing gland to wall ratio in normal and bronchitic patients. Time start: 00:05:19:00 Time end: 00:10:41:00 Length: 00:05:22:00
Segment 3 Reid shows a series of bronchodiagrams comparing the chests of people with and without bronchitis. He also describes the research of Dr Ian Gregg into respiratory function. Time start: 00:10:41:00 Time end: 00:15:53:00 Length: 00:05:12:00
Segment 4 Reid shows slides of rat's lunghs, one normal and one having been exposed to sulphur dioxide as part of an experiment. Time start: 00:15:53:00 Time end: 00:20:16:00 Length: 00:04:23:00
Segment 5 We see a chart detailing an experiment in which mitosis is used as a way of assessing ulceration of the glands. Reid shows goblet cell frequence in the lungs after exposure to tobacco smoke. Time start: 00:20:16:00 Time end: 00:26:16:00 Length: 00:06:00:00
Segment 6 Reid discusses the effects of isoprenaline and pilocarpine on the bronchial glands. Time start: 00:26:16:00 Time end: 00:30:04:00 Length: 00:03:48:00
Segment 7 We see electron micrographs of aspects of the epithelium under the control of motor nerves. Reid concludes by saying that the best way to deal with chronic bronchitis is by prevention rather than cure. Time start: 00:30:04:00 Time end: 00:33:38:21 Length: 00:03:34:21


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