The bronchial epithelium in disease.
About this work
Here, Professor Lynne Reid from the Cardiothoracic Institute, University of London, talks about the bronchial epithelium. A summary accompanying the cassette reads: "Bronchial submucosal gland hypertrophy, together with increase in the number of goblet cells in the surface epithelium and their extension into peripheral airways, are the hallmarks of the human chronic bronchitis. Similar changes in mucus-secreting tissues, as well as increase in the number of cells in mitosis, can both be produced by a variety of irritants although not necessarily to the same degree. These tests offer two methods of 'titrating' epithelial damage. Recently it has been shown that isophrenaline and pilocarpine also produce similar changes but probably because of a different intracellular effect. Recent demonstration of nerve fibres within the bronchial epithelium, some at least motor in type suggests that both epithelial and submucosal glands are under nervous control."