On the pathological anatomy of multiple lymphosarcoma and its status with relation to Hodgkin's Disease / by W.G. MacCallum.

  • MacCallum, W. G. (William George), 1874-1944.
Date:
[1907?]
Catalogue details

Licence: In copyright

Credit: On the pathological anatomy of multiple lymphosarcoma and its status with relation to Hodgkin's Disease / by W.G. MacCallum. Source: Wellcome Collection.

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    In the meshes of this tissue and more or less coherent with it are great numbers of lymphoid cells, which make up the bulk of the cellular tissue. These are similar in every respect to those normally seen in the lymph gland, except that they are sometimes rather irregular in form and show a somewhat elongated nucleus; with the advance in the age of the process the lymphoid cells become less numerous and the gland more fibrous. Scattered among these cells are many much larger cells, with irregular, ragged cell body, com¬ posed of indefinitely granular protoplasm and with a large, sharply outlined, vesicular nucleus. Sometimes this is quite round, more often kidney-shaped or slightly indented, and frequently there are several, as if the main nucleus had given rise to other smaller ones, by a process of budding. Each nucleus has a definite, deeply stained nucleolus, and a number of chromatin granules about its margin. In many cases, but not in all, there are also numerous * eosinophile cells with single or lobulated nucleus. These are scat¬ tered irregularly, often in great profusion, in certain parts of the gland, and sometimes very abundantly in its capsule. Large, multinucleated giant cells occur but rarely, but are sometimes seen. The later stages differ only in the smaller number of the cellular elements, and the predominance of the fibrous tissue. The nodules scattered in the lung tissue, or in the liver or spleen, present precisely the same characteristics. This tissue sometimes presents areas of necrosis apparently due to insufficient vascularization, while in cer¬ tain cases, as mentioned above, there is a terminal infection with the tubercle bacillus, in which case characteristic tuberculous lesions may be grafted on the lesions of Hodgkin’s disease. Undoubtedly this tissue change is such as cannot be mistaken for any of those already mentioned. It has nothing in common with recognized lesions produced by the tubercle bacillus and pieces of the tissue, except from those cases in which there is an obvious secondary tuberculosis when implanted in the tissues of a guinea-pig, give rise to no tuberculosis. We cannot, therefore, agree with Sternberg and others who regard Hodgkin’s disease as merely a peculiar form of tuberculosis. Its distribution is fairly characteristic also, for while the lymph glands, liver, spleen, and, rarely, the lungs, are involved, the kidneys, adrenals, pancreas, digestive tract, bone-