Additional experiments to determine the lesion in quinine blindness / by G. E. de Schweinitz.

  • De Schweinitz, G. E. (George Edmund), 1858-1938.
Date:
[1891]
Catalogue details

Licence: Public Domain Mark

Credit: Additional experiments to determine the lesion in quinine blindness / by G. E. de Schweinitz. Source: Wellcome Collection.

Provider: This material has been provided by UCL Library Services. The original may be consulted at UCL (University College London)

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    [Reprinted from American Ophthalmological Society Transactions, 1891.] ADDITIONAL EXPERIMENTS TO DETERMINE THE LESION IN QUININE BLINDNESS 1 By G. E. de SCHWEINITZ, M.D., OF PHILADELPHIA. With Photo-micrographic studies by William M. Gray, M.D. A communication presented to the College of Physicians of Philadelphia, November, 1890,* contained the results of some experiments which I had made in the endeavor to determine the lesion in quinine blindness. A brief summary of this research is the following: Quinine given hypodermically to dogs in quantities varying from one grain to four grains to the pound, produces blindness in from three to fourteen hours, the earliest appearance of the amaurosis after the injection being three hours. The blindness remained practically complete in one animal for twenty-nine days after a single injection of 3! grains to the pound ; in one there was a slight return of vision after thirty-six hours of blindness. The effects of the drug were ob- tained more quickly and more surely with quin, bimur. carbami- dat. than when the bisulphate was used. A dose exceeding 3f grains to the pound produced death ; one animal perished from a dose of three grains to the pound ; and one dog resisted IJ grains of quinine to the pound given on two successive days, but succumbed when a third similarly proportioned dose was administered. With two exceptions the animals suffered from other symptoms in addition to the blindness, viz : vomiting, * Transactions of College of Physicians of Phila., 1890; also Ophthalmic Review, Feb- ruary, 1891.