Females are mosaics : X inactivation and sex differences in disease / Barbara R. Migeon.

"This is the first book-length discussion of X inactivation, the mechanism that equalizes the expression of genes on the X chromosomes of human males and females." "Although much has been written about the Y chromosome and its role in inducing maleness, little has been written about the blueprint for female development and survival, including X inactivation. Discussions of the basis for sex differences in disease usually do not consider the sex differences in expression of X-linked genes." "Included are in-depth discussions of X inactivation, focused on the molecular mechanisms responsible for chromosome inactivation and the single active X. Also considered are the evolutionary origin of the human sex chromosomes and a genetic portrait of the human X chromosome."--BOOK JACKET.