Remarks on methods of increasing and diminishing the coagulability of the blood : with especial reference to their therapuetic employment / by A.E. Wright.

  • Wright, Almroth, 1861-1947.
Date:
1894
Catalogue details

Licence: Public Domain Mark

Credit: Remarks on methods of increasing and diminishing the coagulability of the blood : with especial reference to their therapuetic employment / by A.E. Wright. Source: Wellcome Collection.

Provider: This material has been provided by The University of Glasgow Library. The original may be consulted at The University of Glasgow Library.

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    The eft'eet of an administration of calcium chloride to a selected number of the members of this family was as follows:— Relationship to the HoBmopliiliac Boy. 6 Coagulation Time be- fore Commencement of Treatment. Temperature-at which the Determination was Made. Date or Dates on which Calcium Chloride was Administered. Dose of Calcium Chlor- ide and Number of Daily Doses. Coagulation Time after Treatment. Temperature at which the Determination was Made. Min. Sec. F. Grammes. Min. Sec. F. Maternal grandmother 68 11 55° 2-11-93 0.6 b.i.d. 5 57° 5 57° 3-11-93 0.6 „ 6 30 52° Mother 28 6 45 55° 2-11-93 0.6 „ 4 35 57° 4 35 57° 3-11-93 0.6 „ 3 25 58° Eldest sister H 45 55° 2-11-93 0.3 „ 9 57° 9 57° 3-11-93 0.3 „ 10 52° Fifth sister ... li 12 20 55° 2-11-93 0.3 „ 10 15 57° 10 15 57° 3-11-93 0.3 „ 7 20 52° Haemophiliac boy himself... 3 23 (?) 55° 2-11-93 0.3 „ 35 (?) 57° 35 (?i 57° 3-11-93 0.6 „ 21 (?) 52° 21 ■?) 52° 4-7-11-93 0.3 „ 29 (?) 41° 29 (.') 41° 13-15-11-93 0.7 „ 45 (?) 42.5° Maternal first cousin (boy) 11 8 20 55° 2-11-93 0.6 „ 4 30 57° It will be noticed that evidence was obtained of increased coagulability of all the members of the family except the haemophiliac boy himself. It is impossible to be certain whether in his case there was any increase of coagula- bility or not for the determinations of coagulability were made at such unfavourable temperatures that it was a matter of difficulty to obtain a correct measure of his coagu- lability. I am indebted to Sir William Jenner, Bart., for the oppor- tunity of studying, and for much help in the study, of these cases. Case ii.—Hsemophilia said to be inherited through the mother. No confirmation of tliis history obtained on comparing the mother's coagu- lation time (31 minutes at 18.5° C.) with -the father's coagulation time (3 minutes 40 seconds, at 18.5° C). Patient. Age. Coagulatiou Time before Treatment. Date on which CaCl2 waa Administered. Dose and Number of Daily Doses. Coagulation Time after Treatment. Temperature at which Determina- tions were Made. Htemophiliac boy 9 Over 60 min. 14-4-94 2 grammes b. i. d. 27 min. 18.5° C. 27 min. 15-4-91 2 grammes b. i. d. 13 min. 18.5° G. Hsemophiliac boy 7 6 min. 40 sec. 14-4-94 2 grammes b. i. d. 4 min. 18.5° 0. It will be seen that the administration of comparatively