Remarks on methods of increasing and diminishing the coagulability of the blood : with especial reference to their therapuetic employment / by A.E. Wright.
- Wright, Almroth, 1861-1947.
- Date:
- 1894
Licence: Public Domain Mark
Credit: Remarks on methods of increasing and diminishing the coagulability of the blood : with especial reference to their therapuetic employment / by A.E. Wright. Source: Wellcome Collection.
Provider: This material has been provided by The University of Glasgow Library. The original may be consulted at The University of Glasgow Library.
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![aneurysm patient in question, I found that under the in- fluence of doses of 4 grammes of calcium cliloride adminis- tered twice daily, the patient's coagulation time decreased from his normal of 6 minutes to a minimum of 4 minutes on the third day of the treatment. On the fourth day coagula- bility became subnormal, and it reverted to its original level when the administration of calcium chloride was stopped. Similar results were obtained with a morning and evening dose of 3 grammes of calcium chloride. Under the influence of these doses coagulability was increased till a coagulation time of 85 minutes came under observation on the fourth day of the treatment. On the next day coagulability again began to decline, and coagulation time stood at 6f minutes on the seventh day of the treatment. The administration of the lime salt was then again sus- pended and coagulability increased (this was probably attri- butable to the elimination of an excess of lime) until the previous maximum coagulability (3| minutes) was reached 24 hours after the administration ot the lime had been sus- pended. After this coagulability reverted to its original level, and coagulation times ranging between 6J minutes and 8 minutes were recorded in the morning and evening deter- minations of the next two days. The administration of cal- cium chloride was now begun again (this time 2 grammes of the salt were administered thrice daily), and eight hours after the administration of the first dose, coagulation time stood at 3^ minutes, and under the influence of this treatment, combined with a more generous diet, coagulability increased gradually but irregularly (for there was a temporary fall caused by changes in diet), till on the 12th, 13th, 14th, 15th, and 16th days of this treatment coagulation times of 4^, 4|, 3^, 2i, and ]i minutes were registered. On the next day after this, though the treatment remained unaltered, coagulability again began to decline, and a few days afterwards the patient passed from under my observation. Inhalation of Cabbonic Acid Gas Increases the Coagulability of the Blood. After establishing^^ the fact of the increase of blood coagu- lability under the influence of carbonic acid by direct obser- vations on the condition of blood coagulability in animals (dogs and rabbits) which were supplied in an alternating manner with ordinary atmospheric air and with atmosphere in which the total nitrogen had been replaced by carbonic acid, and after having verifled that the inhalation of carbonic acid had a similar efi'ect on my own blood and also upon the blood of some children belonging to a hasmophiliac family under my care, I determined to employ the inhalation of the gas as a therapeutic measure in a case of almost desperate haemorrhage which occurred in the hajmophlliac boy who was referred to me for study by Sir William Jenner. The history of the case is as follows: The haemophiliac heredity can be traced back through three generations of maternal ancestors. The child is at present nearly 4 years old, and has suffered from an almost continuous succession of subcutaneous haematomata. In September, 1893, hemor- rhage set in as a result of a fall upon the forehead, which left a scar which was visible for months after. The hemor- rhage was treated by ordinary palliative measures, and finally ceased after lasting some six weeks. The blood is said to](https://iiif.wellcomecollection.org/image/b2146683x_0010.jp2/full/800%2C/0/default.jpg)
