Report of the Committee of Management and Medical Director : 1947 / Papworth Village Settlement.

  • Papworth Village Settlement (Cambridge, England)
Date:
1947
Catalogue details

Licence: Public Domain Mark

Credit: Report of the Committee of Management and Medical Director : 1947 / Papworth Village Settlement. Source: Wellcome Collection.

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    The bacteriological significance of the “limit.” The transition ZN-negativa to Culture + positive. The quantitative effect of F.M. and concentration on the “limit” value etc. The Mechanics of Culture Technique How many tubes of cultures media should be used for each specimen ? What interval should elapse before discarding negative tubes ? Qualitative discrepancies in the tube and co-tube. Quantitative discrepancies : Abso¬ lute discrepancies (one +, co-tube — nega¬ tive) : Frequency distribution of colony counts : Interbatch variations : Micro-posi¬ tives : Micro-negatives. Failure to grow : Contamination rates : Double contaminations. General Aspects of Sputum Examination The scope of this intended third sectional communication is as yet undefined but will cover important aspects omitted in above. Probably the main theme will be “restate¬ ment of bacterial standards.” 2. CANCER AND TUBERCULOSIS Pursuant of work of earlier years a paper “Regional Influences in Cancer” (British journal of Cancer 1947, p. 109) discusses the distribution and characteristics of factors influencing cancer-deaths in various localities. This is the first application of the new method, Rational Study of Regional Influences (Pap- worth Research Bulletin, 1940) and it is the writer’s intention to prepare a paper dealing with the Regional Influences in Tuberculosis, part of the material for which has already been collected. It is satisfying to be able to record that Dr. P. A. P. Moran of the Institute of Statistics, Oxford, has prepared a paper “The Inter¬ pretation of Statistical Maps” (in press) in which the writer’s initial work on Map “Patterns” is developed into a formal statistical technique. This should establish and confirm the essential validity of the method. 3. ZINC IN TUBERCULOSIS The experiment photocols of this latter work have now been reviewed and they disclose some very interesting facts. For example there can no longer be any doubt about the participation of zinc in calcification processes as its relation to Phosphatase Enzyme is brought out most strikingly by comparison with recent work on this enzyme by Dr. Maurice Murnaghan (Blood levels of Ca, P, and alkaline Phosphatase in relation to Tuberculosis Infection— Irish J. of Med. Sc.). Dr. Murnaghan visited the writer here on the instigation of the late Prof Dillon. It is hoped to prepare a paper on this subject as soon as time permits. There has been no new experimental work on zinc during the year. 4. HAEMATOLOGY It has not been possible to make any head¬ way with the “Sedimentation in Wedge Cells” though the requisite special apparatus is now available. An independent memorandum outlining this idea was submitted to the Research Committee seme time ago. The estimations of Post-Transfusion Haema- turia continue. Instituted as a routine check on post-transfusions reactions it is revealing some facts of interest regarding blood prod¬ ucts from thoracoplasty wounds, etc. As a further check on reactions we have commenced measuring post operative Eosinophilia, the counts being made by an accurate method. The “Internal Correlations of the Differential Count in Tuberculosis” is also under study. 5. MISCELLANEOUS Chemical Estimation of Calorie Value of Meals. Statistical Survey of Calorie Value of Diet. Histidine Excretion in the Urine 1. Pregnancy test. 2. Variations with Menses. 3. Variations with A.P. Clinical Chemistry Standard Urinalysis ... Special (quantitative) Urinalysis Blood Chemistry Test Meals, C.S.F., etc., etc.... Food and Drugs Analytical and Research Chemistry Histidinuria ... ... ... ... 528 Post-Transfusion Haematuria ... 288 Milk (Phosphatase, etc.) . 402 Water (Hardness, etc.) . 333 828 125 31 129 74 [21]