A series of experiments made upon the dog with several gout nostrums of the present day, and different preparations of colchicum ... to demonstrate the agency of these substances on the animal oeconomy; and to furnish ... conclusions in reference to the employment of colchicum as a medicine in gout / [Charles Scudamore].

  • Scudamore, Charles, 1779-1849
Date:
[1819]
Catalogue details

Licence: Public Domain Mark

Credit: A series of experiments made upon the dog with several gout nostrums of the present day, and different preparations of colchicum ... to demonstrate the agency of these substances on the animal oeconomy; and to furnish ... conclusions in reference to the employment of colchicum as a medicine in gout / [Charles Scudamore]. Source: Wellcome Collection.

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    of the muscles of the thighs was observed. In half an hour he voided some urine. In little more than an hour, the symptoms were more favourable. In an hour and a half, he seemed so much recovered as to be capable of running many yards, and up a pair of stairs. In three hours, he was discovered to be in a sound sleep. Some greenish yellow mucus appeared around the mouth. In five hours, he ran about from place to place as if restless, and appeared debilitated. In seven hours and a quarter, we were much surprised to find that he had expired. This dog' lost six ounces of blood in the operation. There was a small sediment in the bottle of the tincture, which was shaken up, and injected with the fluid. Dissection*—The oesophagus appeared in a natural state. The whole surface of the stomach exhibited marks of in¬ flammation, and the mucous membrane, towards the pylo¬ rus, was almost gangrenous; the stomach contained bile and mucus; the duodenum, near the stomach, was much inflamed; the other portion but slightly. The jejunum, at its commencement, was highly inflamed, and covered with an abundance of coagulated albumen. The inflammation extended through the whole course of the jejunum and ilium, but gradually diminished. In the colon the appear¬ ances of inflammation increased; the caecum was slightly inflamed; and the rugae of the rectum exhibited numerous red points. The lungs bore slight appearances of inflamma¬ tion ; the liver was partially inflamed; the urinary blad¬ der was much contracted; the brain was in a natural state, Exp. 3.—Reynolds' Specific.—-At twenty minutes past one/?, m. a hundred and eighty drops of this tincture, measuring two drachms, were injected into the jugular vein of a young mongrel dog. He passed at the moment a natural alvine discharge. At three o'clock he had B