Genetics in obstetrics and gynecology / Joe Leigh Simpson [and others].

Date:
[1982], ©1982
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Licence: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

Credit: Genetics in obstetrics and gynecology / Joe Leigh Simpson [and others]. Source: Wellcome Collection.

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    INDEX / 311 etiologic categories, 1 Mendelian inheritance, 23-29 polygenic or multifactorial inheritance, 29-34 Genital ambiguity. See also Pseudohermaphroditism; Sexual differentiation, disorders of in gonadal dysgenesis, 165 Genome, 36 Germ cell tumors, 152-153. See also Dysgerminoma; Gonadal dysgenesis Germinal cell aplasia, 192 Glucose-6-phosphate dehydrogenase (G6PD] deficiency, 39 Glycogen storage disease, 115-116, 118 Gonadal dysgenesis, 150, 176-186 acquired diseases in, 180 almost-normal male genitalia in, 165 ambiguous genitalia in, 165 asymmetric, 165 chromosomal complements in, 176 deletions of X long arm, 184 deletions of X short arm, 182-184 embryonic origin by increased oocyte attrition, 180-181 external genitalia in, 177-178 gonads in, 177 male pseudohermaphroditism in, 164-165 metabolic changes in, 180 mixed, 165 neoplasms associated with, 153, 165, 177, 178, 186 mosaicism in, 181 pathological considerations in, 177— 180 phenotype-karyotype correlations in, 184-185 sex chromosome abnormalities in, 180-185 somatic features associated with, 178-180 XX, 185-186 XY, 186 cancer and, 186 with Y chromosome line, 164—165 45,X, 180-181 Gonadoblastoma, 153. See also Gonadal dysgenesis Gonadotropins, isolated deficiency of, 191, 192 Granulomatous disease, chronic, prenatal diagnosis of, 118 Granulosa cell tumors, 153-154 Gynecologic disorders, common. See also Pregnancy; and specific disorders genetics of, 142-155 Haloperidol, teratogenicity of, 259 Hand-foot-uterus syndrome, 149 Hardy-Weinberg equilibrium, 27-28 Heart. See Congenital heart disease; Coronary artery disease Hemizygosity, definition of, 28 Hemoglobin Bart, 36 Hemoglobin chains, 35 Hemoglobin С disease, 38 Hemoglobin H, 36 Hemoglobin S-jS-thalassemia, 38 Hemoglobin SC disease, 37-38 Hemoglobinopathies, 35-38 molecular gentics of, 35-37 prenatal diagnosis of, 113-114, 118 reproductive implications in, 37—38 restriction endonuclease in evaluation of DNA in, 5, 106— 107 Hemolytic anemia effects on reproduction, 38—39 prenatal diagnosis of, 119 Hemophilia, 39-40 heterozygote testing in, 40 prenatal diagnosis of, 115, 119 in women, 40 Heparin, teratogenicity of, 262 Hepatolenticular degeneration. See Wilson disease Hereditary spherocytosis, 38 Heritability, definition of, 33-34 Hermaphroditism, 21. See also Pseudohermaphroditism; Sexual differentiation, disorders of true, 174-175 chromosomal complement in, 174, 175 etiology of, 175 phenotype, 174-175 Hernia diaphragmatic, 90 inguinal, 91