Manual of hypodermic medication / by Roberts Bartholow.

  • Bartholow, Roberts, 1831-1904.
Date:
1869
Catalogue details

Licence: Public Domain Mark

Credit: Manual of hypodermic medication / by Roberts Bartholow. Source: Wellcome Collection.

Provider: This material has been provided by the Francis A. Countway Library of Medicine, through the Medical Heritage Library. The original may be consulted at the Francis A. Countway Library of Medicine, Harvard Medical School.

    114/172 (page 100)
    The solutions of strychnia, much less than the other alkaloids, are spoiled by the development of a peni- cillum, but this takes place only after long standing and exposure to the air. Dose.—As is the case with other alkaloids, authori- ties differ very much as to the quantity of strychnia proper for a hypodermic injection. Lorent employed from ^ to*Txa of a grain of nitrate and muriate. Courty and Eulenberg have used so much as |- of a grain at a dose. These large doses are apt to produce trismus and opisthotonos. The doses used by Hunter varied from -fa to y\ of a grain. Dr. Echeverria, of New York, injected, in the cases of paralysis treated by him, £0 to ^ of a grain—the latter dose producing in the patient, a boy, toxic symptoms. I have injected ^ of a grain. This has seemed to me the maximum quantity which can be used with a proper regard to the safety of the patient. Generally in adults I inject 5 minims of my solution, or Jg of a grain. Physiological Effects.—When injected under the skin, a sensation of heat and smarting persists for some time in the part. The skin also becomes red in the neighborhood of the puncture; a subjective sensa- tion of warmth is perceived in the limb, and an actual rise in temperature may be noted. At the same time erection of the hair-follicles (cutis anserina) takes place. In a few seconds pain or distention is felt in the abdomen, intestinal movements and loud borborygmi occur, just as is the case so frequently after the hypo- dermic injection of the narcotic alkaloids. Next the pupils dilate, deep-seated pain and throbbing are