Serum diagnosis of syphilis and luetin reaction : together with the butyric acid test for syphilis / by Hideyo Noguchi.

  • Noguchi, Hideyo, 1876-1928.
Date:
[1912], ©1912
Catalogue details

Licence: Public Domain Mark

Credit: Serum diagnosis of syphilis and luetin reaction : together with the butyric acid test for syphilis / by Hideyo Noguchi. Source: Wellcome Collection.

Provider: This material has been provided by the Francis A. Countway Library of Medicine, through the Medical Heritage Library. The original may be consulted at the Francis A. Countway Library of Medicine, Harvard Medical School.

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    VI. VARIOUS FORMS OF THE COMPLEMENT-FIXATION TEST AS APPLIED TO THE SERUM DIAG- NOSIS OF SYPHILIS. As was pointed out in the last chapter, it is erroneous to think that ahnost any hgemolytic system can be used to test the binding power of antigen-anti- body combination for complement. On the contrary the experimenter must be aware of the disturbing eifect that results from the use of a hsemoljiiic system in which alien erythrocytes naturally susceptible to the h^emolytic action of human serum are employed. Here the amount of the amboceptor becomes uncon- trollable and extremely variable, for the reason that the amounts of the natural amboceptor contained in the serum to be examined are unknown and variable. The second important point which the experimenter must always bear in mind before employing a heemolytic system is the quality of complement in regard to fixation phenomenon. As was stated in the last chapter, different complements vary con- siderably in their activity and fixability. The selec- tion of the haemolytic system is, therefore, one of the most important problems that involve the comple-