Serum diagnosis of syphilis and luetin reaction : together with the butyric acid test for syphilis / by Hideyo Noguchi.

  • Noguchi, Hideyo, 1876-1928.
Date:
[1912], ©1912
Catalogue details

Licence: Public Domain Mark

Credit: Serum diagnosis of syphilis and luetin reaction : together with the butyric acid test for syphilis / by Hideyo Noguchi. Source: Wellcome Collection.

Provider: This material has been provided by the Francis A. Countway Library of Medicine, through the Medical Heritage Library. The original may be consulted at the Francis A. Countway Library of Medicine, Harvard Medical School.

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    antigen are the same as those obtained with several there would be no chance of obtaining variable results, but, in reality, the reactions vary considerably accord- ing to whether one uses one or several antigen units. This is especially so with a weaker syphilitic serum. In my opinion it is absolutely necessary to use several antigen doses in order to get uniform results with any specimen, because the weakest reaction escapes detec- tion, unless one employs, at least, over four antigen units. It is understood, however, that no oversensi- tive reaction ought to be allowed to occur in using many antigen units. Fortunately, according to our extensive experience, the use of a suitable antigen— prepared by my method—causes no such an undue sensitiveness. One might think that the same principle can be applied also to the Wassermann system, but this is impossible because of the constant presence of anti- complementary substances in the extract used in that system. The Quantity of Antigen for Fixation Test.—As stated above it is essential for obtaining uniform results to employ more than four antigen units. To fulfil this requirement I recommend the use of 0.1 c.c. of 0.3 per cent, suspension of the aceton-insolu- ble tissue lipoids whose suitableness as antigen has previously been determined in the manner already described. In this quantity of the emulsion there will