Some problems of intermediary metabolism.

  • Chittenden, R. H. (Russell Henry), 1856-1943.
Date:
[1905]
Catalogue details

Licence: Public Domain Mark

Credit: Some problems of intermediary metabolism. Source: Wellcome Collection.

Provider: This material has been provided by the Augustus C. Long Health Sciences Library at Columbia University and Columbia University Libraries/Information Services, through the Medical Heritage Library. The original may be consulted at the the Augustus C. Long Health Sciences Library at Columbia University and Columbia University.

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    COOH Phcnylalanin CH (HO)C HC /\ V CH C(OH) c CH, I CHOH I COOH Uroleueic acicl CH2 I CHOH I COOH Phenyl-a-lactic acicl CH (HO)C [ ^|CH HC I J C(OH) C I CH2 I COOH Homocentisic acid Especially interesting and suggestive in this schematic representation of the intermediary changes from phcnylalanin to homogcntisic acid is the formation of phenyl-a-lactic acid. The splitting off of nitrogen from the alanin, i. e., its deamidization, takes place at this stage with the resultant formation of a non-nitrogenous acid, a complex of the aro- matic group and rt-lactic acid. We thus see opened up, as stated by Falta, a new point of view regarding the forma- tion of sugar from proteid. Between lactic acid and dex- trose there are many obvious physiological connections arid it is quite conceivable, to say the least, that a portion of the lactic acid originating in this manner may in the liver