Serums, vaccines and toxines in treatment and diagnosis / by Wm. Cecil Bosanquet ... and John W.H. Eyre.

  • Bosanquet, W. Cecil (William Cecil), 1866-1941.
Date:
1910
Catalogue details

Licence: Public Domain Mark

Credit: Serums, vaccines and toxines in treatment and diagnosis / by Wm. Cecil Bosanquet ... and John W.H. Eyre. Source: Wellcome Collection.

Provider: This material has been provided by the Harvey Cushing/John Hay Whitney Medical Library at Yale University, through the Medical Heritage Library. The original may be consulted at the Harvey Cushing/John Hay Whitney Medical Library at Yale University.

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    normal variety. Bright and Templex had previously noted that the bacilli are maimed, but not killed, by agglu- tination. Both agglutinins and bacteriolysins fall out with one of the globulin-fractions when serum is precipitated with ammonium sulphate. Thus the typhoid agglutinin falls out with the euglobulin in the serum of goats and rabbits, but with the pseudo-globulin in the serum of the horse. Cholera-agglutinin is precipitated with the euglobulin in the serum of both horse and goat.3 Maternal transmission of immunity.—The ques- tion of the transmission of immunity from mother to off- spring is one of considerable interest, but is not yet satis- factorily elucidated. Agglutinating power is not usually transmitted in the case of enteric fever, nor in tuberculosis ; but occasionally such transference is found.3 Hsemolysins are transmissible in, animals (Kreidl and Mandl *), and immunity to diphtherial toxine (six out of twelve guinea- pigs, Anderson 5) : so too is supersensibility to horse-serum, according to this last observer. Immune bodies of different kinds may pass into the milk : thus Courmont and Cade 6 found that agglutinins were transferred to an infant through the milk of a wet-nurse, and Salge 7 finds that diphtherial antitoxine may be so transmitted and absorbed by the infant. According to v. Eisler and Sohma 8 opsonins are not transmitted by the mother to the fcetus in utero, but they are present in the milk. In all these cases the properties conferred are merely passive and are soon lost by the i Brit. Med. Journ., 1S97, i. 206. 2 Pick, Hofm. Beitr., 1901, p. 381. 3 Rodhain, ibid., 1903, iii., Hft. 3. 4 Wien. /elm. TT'oc/t., 1904, No. 22, p. 611. 5 Bull. Hyg. Lab. U.S. Pub. Health and Mar. Hosp. Serv., 1906, No. 30. e C.B. Soc. Biol., Nov. 25, 1S99. 7 Jahrb.f. KinierheiVc, 1904, lx. 1. s Wien. Min. ll'ock, 1908, No. 19. c