The Friedmann treatment for tuberculosis : a report of the board appointed for its investigation / by John F. Anderson and Arthur M. Stimson.

  • Anderson, John F., 1871-1958
Date:
1914
Catalogue details

Licence: In copyright

Credit: The Friedmann treatment for tuberculosis : a report of the board appointed for its investigation / by John F. Anderson and Arthur M. Stimson. Source: Wellcome Collection.

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    work were able to go back to work a few weeks after the first injection.” 30. “ Under the influence of the injection, cough and expectoration disappeared.” 31. “At the same time the auscultatory phenomena, such as rales, became better gradually and disappeared.” 32f. “ In those cases of tubercular skin disease which are probably often due to the bovine bacillus, * * * the specific hypersuscepti¬ bility is often very marked and thereby the taking hold of the remedy is made difficult. The result is obtained in these cases, how¬ ever, by the simultaneous method of injection.” 33. “After the preparation had shown itself harmless within the widest limits in man and animals, and after the progressive and permanent cures in man were beyond question, I made use of the remedy for purposes of protective inoculation in children. So far 335 children from 1 hour to 3 years of age have been inoculated. Although the oldest series were inoculated more than a year ago, not the slightest trace of beginning scrofula or tuberculosis has appeared in any case.” 34. “ In contrast to these weakly virulent bacilli ” (experiments of Orth and Rabinowitsch), “the completely avirulent bacilli which enter into the composition of the preparation used by me on man, are never to be found in the guinea pig body even after a short time. It is to be emphatically stated that my preparation is completely harmless for guinea pigs; even if one injects several times the dose used for man, the animals are found altogether sound, if killed years afterwards.” 35. “These animals never show cavitation following virulent in¬ jection.” 36. “Although they do not possess full immunity against the se¬ vere artificial infection, still while untreated animals infected with tuberculosis die on the average after 110 days, they are kept alive 363 days, near a year, by a single therapeutic injection of this remedy. And in the same way a single immunizing injection is sufficient to preserve the life of the animal previously treated and subsequently injected with highly virulent human tubercle bacilli, more than four times as long as the control; that is, the animal only infected with human tubercle bacilli.’-’ In the discussion repeated demands were made upon Dr. Fried¬ mann for a statement of the exact nature of his remedy. He still refrained from a definite statement, but his language leads one to infer that his bacillus is not of human origin, but is derived from a 'naturally infected turtle, and is the third which he has isolated, originally of very low virulence, but now absolutely avirulent. In