Leprosy: type 1 (reversal) leprosy reaction

  • SB Lucas
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Leprosy: type 1 (reversal) leprosy reaction. SB Lucas. CC0 1.0 Universal. Source: Wellcome Collection.

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Tuberculoid (TT) leprosy: type 1 (reversal) leprosy reaction This high power view of a skin section shows a vertical nerve with classic neuritis. The remaining Schwann cells, plus their axons, are seen as thin, wavy bands. These cells are surrounded by giant cell granulomas and peripheral lymphocytes. H&E stain. The presence of the numerous, large Langhans' giant cells is evidence of a type 1 reaction, i.e. borderline tuberculoid (BT) upgrading to TT. See image W0043361 for a low power view of this section.

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