Transmission of protein hypersensitiveness from mother to offspring. I, Critique of placental permeability / by Bret Ratner, Holmes C. Jackson, and Helen Lee Gruehl from the Department of Physiology, University and Bellevue Hospital Medical College, New York University, New York City.

  • Ratner, Bret, 1893-1957
Date:
[1927?]
Catalogue details

Licence: In copyright

Credit: Transmission of protein hypersensitiveness from mother to offspring. I, Critique of placental permeability / by Bret Ratner, Holmes C. Jackson, and Helen Lee Gruehl from the Department of Physiology, University and Bellevue Hospital Medical College, New York University, New York City. Source: Wellcome Collection.

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    CONCLUSIONS 1. The passage of heterologous substances through the pla¬ centa is a physiologic function and not a pathologic one. 2. The placenta is permeable to antitoxins, precipitins, bac- teriolysins, heterologous proteins, protein sensitizing antibodies, etc., in man, guinea pigs, and rabbits. 3. The placenta is not permeable to these substances in cows, goats, and sheep. 4. A histologic difference in the placenta in the various species is offered to explain this difference in permeability. In man and rodentia there is a single cell membrane separating the maternal from fetal circulation, and in ruminants there are three cell layers separating these circulations. REFERENCES (1) Rosenau, M. J., and Anderson, J. F.: A study of the cause of sudden death following the injection of horse serum. Hereditary transmission of the susceptibility in guinea pigs. Hyg. Lab. Bull., 1906, 29, 73. (2) Wernicke, E.: fiber die Vererbung der kiinstlich erzeugten Diphtherie- Immunitat bei Meerschweinen. Festschrift zur 100 jahrigen Siftungs- feier des Medizinische-chirurgischen Friedrich-Wilhelms-Instituts, p. 525, Berlin, 1895. (3) Smith, Theobald: Degrees of susceptibility to diphtheria toxin among guinea pigs; transmission from parents to offspring. Jour. Med. Res., New Series, 8, 341. (4) Anderson, J. F.: I. Maternal transmission of immunity to diphtheria toxin. Hyg. Lab. Bull., 1906, 30, 7. (5) Anderson, J. F.: II. Maternal transmission of immunity to diphtheria toxin and hypersusceptibility to horse serum in the same animal. Hyg. Lab. Bull., 1906, 30, 18. Anderson, J. F.: Simultaneous transmission of resistance to diphtheria toxin and hypersusceptibility to horse serum by the female guinea pig to her young. Jour. Med. Res., 1906, 10, 259. (6) Gay, F. P., and Southard, E. E.: On serum anaphylaxis in the guinea pig. Jour. Med. Res., 1907, 11, 143. (7) Otto, R.: Zur Frage der Serum-Ueberempfindlichkeit. Miinch. med. Wchnschr., 1907, 54, 1665. (8) Lewis, P. A.: Induced susceptibility of the guinea pig to the toxic action of the blood serum of the horse. Jour. Exper. Med., 1908, 10, 1. (9) Schenck, F.: Uber den Ubergang der Anaphylaxie von Vater und Mutter auf das Kind. Miinch. med. Wchnschr., 1910, 67, 2514. (10) Wells, H. Gideon: Studies on the chemistry of anaphylaxis. III. Experi¬ ments with isolated proteins especially those of the hen’s egg. Jour. Infect. Dis., 1911, 9, 147.