Uric acid as a factor in the causation of disease : a contribution to the pathology of high arterial tension, headache, epilepsy, mental depression, gout, rheumatism, diabetes, Bright's disease, and other disorders / by Alexander Haig.

  • Haig, Alexander, 1853-1924.
Date:
1892
Catalogue details

Licence: Public Domain Mark

Credit: Uric acid as a factor in the causation of disease : a contribution to the pathology of high arterial tension, headache, epilepsy, mental depression, gout, rheumatism, diabetes, Bright's disease, and other disorders / by Alexander Haig. Source: Wellcome Collection.

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    urate accumulations of previous years are got again into solu- tion in the blood, and passed through the kidney into the urine. Since I first observed that I was able to alter the excretion of uric acid from hour to hour or day to day at pleasure, I have investigated the effects of a very large number of drugs upon it, and I have summarised my results in the general statement that all substances which increase the solubility of uric acid increase its excretion, and clear it out of the body, while con- --Hour, ending. ■70 23 4 120 ■55 18 3 90 UKIC AC ■40 13 2 60 UffE URINARY WATL ■25 8 / 30 Acion S4S W-45 11-45 IZ4S I4S Z-45 345 A s / , A n / ./ V /I ^ 1 AN —1 A >— /?-- ft Pig. 1.—Natural Plus Excretion of Uric Acid in the Alkaline Tide. Breakfast ended 9.50 a.m. Lunch, ended 2.10 p.m. Two and a-half miles sharp walking 3.0 to 3.45 p.m. ; perspiration, and low tension pulse after walk. Total urinary water 527 cubic centimetres. Total urea 118 grains. Total uric acid 5.0 grains. Relation of uric acid to urea 1 to 23.6. versely, all substances which diminish its solubility diminish its excretion, and tend to produce its retention in the body and accumulation in various organs and tissues. And now in speaking of the action of drugs I shall divide them into (1) those that increase, and (2) those that decrease excretion, and having first enumerated those in each class shall say a few words as to the action of the individual drugs in turn.