Some aspects of lymphadenoma (Hodgkin's Disease) / by H.D. Rolleston.

  • Rolleston, Humphry Davy, Sir, 1862-1944.
Date:
[1911?]
Catalogue details

Licence: In copyright

Credit: Some aspects of lymphadenoma (Hodgkin's Disease) / by H.D. Rolleston. Source: Wellcome Collection.

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    T5 the disease is confined to the retroperitoneal glands, as in a case mentioned by McDonald in which biliary cirrhosis was described as resulting therefrom. The jaundice may vary from time to time, presumably because lymphatic glands in the portal fissure or along the course of the common bile duct become larger or smaller in the same way as the more easily palpable glands are known to do. In a girl aged 7 years under rr^ care with enlarged glands in the neck and axillae and enlargement of the liver and spleen there were febrile attacks at irregular intervals of a week to a fortnight, with increase in the size of the external lymphatic glands and very definite jaundice. As there was no enlargement of the gall-bladder the conclusion seemed justified that the pressure was exerted on the bile ducts above the opening of the cystic duct, and probably in the portal fissure.42 In a case of advanced lymph- adenoma the jaundice almost disappeared a few days after the injection of Ehrlich-Hata “ 606,” or dioxydiamido-arseno-benzol. In abdominal lympliadenoma there is usually enlargement of the spleen, and, less frequently, of the liver in addition. As the splenic enlargement may be the most obvious or even the sole physical sign, a few words may be devoted to this subject. When chronic splenic anaemia of adults was first described it was regarded as a splenic form of lympliadenoma or lienale pseudo-leukaernia. It is now known that this interpretation is incorrect, for the morbid changes in the spleen in chronic splenic anaemia are not those of lymphade- noma. Symmers,43 however, has recorded what appears to be a unique case of primary lymphadenoma of the spleen in a girl aged 18 years, who, three years before her death from splenectomy, passed clots of blood by the bowel and noticed a lump in the abdomen. The clinical resemblance to chronic splenic anaemia must have been exact. The rare cases in which the retroperitoneal lymphatic glands and the spleen are the sole or main sites of the lymphadenomatous change may simulate chronic splenic anaemia and Band’s disease very closely. Parkes Weber 44 described a remarkable case of 42 Rolleston : Proc. Roy. Soc. Med., Lond., 1909, II. (Clin. Sect.), 155. 43 Symmers, D: Arch. Int. Med., Chicago, IV., 1909, 218. 44 Weber: Proc. Roy. Soc. Med., Lond., 1911, IV. (Clin. Sect.), 70, and personal communication.