Volume 1

A clinical treatise on diseases of the liver / by Fried. Theod. Frerichs ; translated by Charles Murchison.

  • Frerichs, Friedrich Theodor, 1819-1885.
Date:
1860-1861
Catalogue details

Licence: Public Domain Mark

Credit: A clinical treatise on diseases of the liver / by Fried. Theod. Frerichs ; translated by Charles Murchison. Source: Wellcome Collection.

    188/440 (page 156)
    lay scattered throughout the parenchyma, which, when more highly magmfied, were found to be hepatic ceUs deeply impregnated with colourmg-matter. In addition to the greatly distended thick-waUed büe ducts, round or elongated spaces of a brown colour were observed at many places, which I regarded as the cross sections Ol the smaUest excretory ducts filled with stagnating bile. The hepatic ceUs were everywhere intact. Some of them were pale and softened, but in no way abnormal; but most of them were loaded with büe. This consisted of yeUow or brown granules, either isolated or adhering in dense groups, in the interior of the ceU; m a few of the ceUs only was a nucleus visible. Many of the ceUs contained abundant deposits of spherical, angular, or cylin- dncal little masses, of a yeUow, brown, or green colour. In several, the colouring-matter was distributed in a uniform manner. Where the nucleus was visible it sometimes appeared pale, at other times tinged with green or yellow. ^ The deposits of bile external to the cells were of various forms and tints; most of them were cyKndrical, straight, or bent, in some in- stances ramified, and occasionally furnished with bulging prominences; their colour was yeUow, brown, ochre, or green. One would have been inclined to have taken these for casts of the most delicate of the bile ducts, had not this supposition been contradicted by the presence of similar formations in the interior of the cells. Along with these elongated forms other deposits were observed, which were rounded, club-shaped or angular. These deposits were of tolerable consistence; by compression between two glass plates, they could be split up and crushed to pieces. Although the substance of the liver was not chemically examined for leucine, until after it had been kept for two days during the warm weather of the month of August, this substance was found in considerable quantity. The spleen was somewhat enlarged, and presented a brownish-red colour and firm consistence. The mucous membrane of the gastro- intestinal canal was covered with a layer of grey mucus of consider- able thickness; the mucous membrane itself was for the most part pale, and contained but little blood; at certain spots only was it much congested. Nothing abnormal could be detected in the duodenum. The kidneys were of the usual size, their outer surface was smooth, and their parenchyma was of a dirty greenish-yellow colour. The epithelium of the uriniferous tubes had undergone extensive fatty