Normal human blood serum as a curative agent in hemophilia neonatorum : a preliminary report, with suggestions for its use in other conditions / by John Edgar Welch.

  • Welch, John Edgar.
Date:
1910
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Licence: In copyright

Credit: Normal human blood serum as a curative agent in hemophilia neonatorum : a preliminary report, with suggestions for its use in other conditions / by John Edgar Welch. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    rhage in the neck increased, and fresh ones appeared on the scalp and right wrist. On the fifth day slight bleeding from the nose; one spot was noticed on the right knee and left elbow. Normal human serum was injected as follows: On the fourth day, two days after bleeding began, 35 c.c. in three doses; on the fifth day, 20 c.c. in two doses; on the sixth day, 29 c.c. in two doses; on the seventh day, 27 c.c.; on the eighth day, 12 c.c.; total, 123 c.c. in five days (Fig. 6). There was no more bleeding after the fifth day, and the child was discharged on the thirteenth day normal. Fig. 6.—Temperature and weight charts of Case VI. Case VII.—First child; female; full term; normal labor. Bleeding from the cord and rectum began on the fourth day. On the fifth day bleeding from the vagina and rectum, and two subcutaneous hemorrhages appeared on the left side of the thorax. On the sixth day profuse bleeding from the cord and slight bleeding from the rectum. There was no bleeding on the seventh and eighth days, and no serum was administered in consequence. On the ninth day there was vomiting of blood and slight bleeding from the rectum. On the tenth day profuse bleeding from the cord, vomiting of blood, and bleeding from the rectum, two subcutaneous hemorrhages on the right side of the thorax, and others on the elbows and on the back. No further bleeding after the tenth day. Normal human blood serum was administered subcutaneously as follows: On the fifth day,