Volume 2

A general system of toxicology : or, a treatise on poisons, found in the mineral, vegetable, and animal kingdoms, considered in their relations with physiology, pathology, and medical jurisprudence / by M.P. [sic] Orfila.

  • Orfila, Matthieu Joseph Bonaventure, 1787-1853.
Date:
1816-17
Catalogue details

Licence: Public Domain Mark

Credit: A general system of toxicology : or, a treatise on poisons, found in the mineral, vegetable, and animal kingdoms, considered in their relations with physiology, pathology, and medical jurisprudence / by M.P. [sic] Orfila. Source: Wellcome Collection.

Provider: This material has been provided by The University of Leeds Library. The original may be consulted at The University of Leeds Library.

    321/604 (page 289)
    1 the symptoms which precede dissolution, are the same as )se described in the first experiment. Death takes place newhat later if the Antiar has been injected into the pleura, into one of the veins of the mesentery; but in every nee are observed vomitings, purging, cries, and convul- s. 'xperiment 5th. When a few drops of Antiar diluted with r, are injected into one of the carotids of a dog, the lal utters a cry at the moment; he experiences no vomit- ;,; the head is twisted; the occiput is bent back upon the T; the neck and trunk are curved into the shape of an S; 1 paws grow stiff, and are occasionally agitated. Death 3 place in less than five minutes. The injection of the ar into the substance of the brain, produces the same ts as the injection into the carotid. 2. It results from these facts, t. That the Antiar is extremely poisonous when injected the carotid artery, the substance of the brain, or the lar vein; that it is less so injected into the pleura; still iwhen applied to the cellular texture; and much less still taken into the stomach ; d. That it is absorbed, carried into the circulation, and I upon the brain and spinal marrow; which is proved by doss of the senses, by the acute cries, by the turning back )ntortion which the head experiences, and by the twitch- fef the muscles of the face ; d. That it acts also as an emetic. 1. Brodie is of opinion, that the Upas-Antiar acts on the which it renders insensible to the action of the blood, ounds his opinion on this circumstance, that very shortly the application of the Upas, the contractions of the are irregular, intermittent, then become weak, and : immediately after death: this organ is then found dis- d by a great quantity of blood. (Philosophical Transt , p. ]96,2/ear 1811.) u 2